{"id":"W2809211544","doi":"10.1093/neuonc/noy059.501","title":"MBRS-57. TARGETING METABOLIC ADAPTATION IN MYC/MYCN AMPLIFIED PEDIATRIC MEDULLOBLASTOMA AND NEUROBLASTOMA","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of British Columbia","funders":"","keywords":"Neuroblastoma; Cancer research; Gene knockdown; Medulloblastoma; Pediatric cancer; Biology; Mediator; Synthetic lethality; Cell culture; Gene; Cell biology; Cancer; Genetics; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002069617,0.0004452753,0.00057606,0.0004446026,0.0001797664,0.0004272716,0.0003665062,0.0002948604,0.002805501],"category_scores_gemma":[0.000144733,0.000265936,0.000391235,0.0004380099,0.000190289,0.0001551869,0.0003015562,0.0006590723,0.001100567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007091971,"about_ca_system_score_gemma":0.0008313218,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004750943,"about_ca_topic_score_gemma":0.01202972,"domain_scores_codex":[0.9998022,0.00001535128,0.00001471036,0.00003562541,0.00009096088,0.00004126013],"domain_scores_gemma":[0.9999397,0.000004996232,0.00001850692,0.00000713306,0.00000880791,0.00002086378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002238641,0.0004023536,0.002914495,0.0005596656,0.0001125843,0.0002859678,0.00005309249,0.001323224,0.9491192,0.0005864713,0.003474754,0.03892961],"study_design_scores_gemma":[0.0007278295,0.002995557,0.04765193,0.0001806924,0.0003199423,0.001533709,0.0001281706,0.004292092,0.8237451,0.000257269,0.1181285,0.00003924996],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9514869,0.02135614,0.003986478,0.0006567005,0.0002282002,0.0003759553,0.01082847,0.0010434,0.01003773],"genre_scores_gemma":[0.939631,0.01648352,0.00631965,0.0003236727,0.00003702835,0.0004500033,0.02500055,0.0001448154,0.01160964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004750943,"threshold_uncertainty_score":0.009446561,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0272576364854346,"score_gpt":0.3186279216659522,"score_spread":0.2913702851805176,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}