{"id":"W2809222016","doi":"10.2337/db18-0124","title":"Histone H3 Serine 10 Phosphorylation Facilitates Endothelial Activation in Diabetic Kidney Disease","year":2018,"lang":"en","type":"article","venue":"Diabetes","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Institute of Nutrition, Metabolism and Diabetes; Heart and Stroke Foundation of Canada; Banting and Best Diabetes Centre, University of Toronto; Kidney Foundation of Canada; Diabetes Canada","keywords":"Histone H3; Downregulation and upregulation; Phosphorylation; CCR2; Cancer research; Biology; Endocrinology; Internal medicine; Cell biology; Chemistry; Molecular biology; Histone; Chemokine; Chemokine receptor; Medicine; Immunology; Inflammation; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001077464,0.0001633073,0.0002355259,0.0001553228,0.00006373725,0.00002057289,0.00005424458,0.0000488042,0.001055658],"category_scores_gemma":[0.0007437541,0.0001432964,0.00008537472,0.0002467542,0.0001539298,0.000173457,0.00002861107,0.00008224026,0.000279393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009560948,"about_ca_system_score_gemma":0.0001015154,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003455784,"about_ca_topic_score_gemma":0.000001960673,"domain_scores_codex":[0.9989281,0.00003733531,0.0002389389,0.0002711221,0.000228784,0.0002957556],"domain_scores_gemma":[0.9991798,0.00006398103,0.00006120064,0.0002381863,0.0001190509,0.0003378045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001137541,0.0006956901,0.672836,0.0009049412,0.00008275279,0.00001569995,0.0007309727,0.00001149872,0.2923206,0.0002838607,0.006338267,0.02464214],"study_design_scores_gemma":[0.001781011,0.0004179108,0.8533906,0.0004564766,0.00008387097,2.047568e-7,0.00006132884,0.001333252,0.1262542,0.001212511,0.01475023,0.0002584243],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966517,0.0005582373,0.00001291044,0.001241199,0.0001397835,0.0003088492,0.00009551854,0.00007432683,0.0009174389],"genre_scores_gemma":[0.9968204,0.00004107195,0.00007956014,0.0006725198,0.0002510301,0.00006548833,0.000288495,0.00002108898,0.001760282],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1805546,"threshold_uncertainty_score":0.9998575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009982498678820591,"score_gpt":0.2580535280884755,"score_spread":0.2480710294096549,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}