{"id":"W2809237949","doi":"10.1016/j.cell.2018.05.052","title":"LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"Cancer-related molecular mechanisms research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":679,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Cancer Institute; National Institutes of Health; National Institute of General Medical Sciences; Boston Children's Hospital","keywords":"Biology; Blockade; Immune checkpoint; Cancer research; Chromatin; Vorinostat; Gene silencing; Immunotherapy; Histone; Immune system; Immunology; Histone deacetylase; Receptor; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000139278,0.0002973095,0.0003056291,0.000307604,0.000184248,0.000420388,0.0002003862,0.0003715914,0.003976186],"category_scores_gemma":[0.000111093,0.0001706805,0.0003339894,0.0001434876,0.00040494,0.0002743367,0.0003334183,0.001029097,0.0009725189],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003662545,"about_ca_system_score_gemma":0.000235208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000177887,"about_ca_topic_score_gemma":0.000488163,"domain_scores_codex":[0.9998119,0.00002011121,0.00001542791,0.00004572655,0.0000317202,0.00007518886],"domain_scores_gemma":[0.9998432,0.00003169542,0.0000343356,0.00003322954,0.000006634744,0.0000507605],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000228444,0.00004032946,0.0002190462,0.00002765941,0.000005051912,0.00003866996,0.000006926006,0.00005084477,0.9981981,0.000216038,0.0000834036,0.0008855152],"study_design_scores_gemma":[0.00002005027,0.0001748753,0.001839309,0.000002407615,0.00001010722,0.000153519,0.00002021643,0.0003160226,0.9956384,0.00007790447,0.001743976,0.000003196277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931631,0.0008912403,0.002102427,0.0002581713,0.0000911786,0.00002107952,0.0006939282,0.0003875488,0.002391316],"genre_scores_gemma":[0.9967808,0.0001649553,0.0005507793,0.00005317405,0.00001037081,0.00001359548,0.0002906297,0.00002943624,0.002106358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003976186,"threshold_uncertainty_score":0.01330173,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009287189631090549,"score_gpt":0.2549240203864309,"score_spread":0.2456368307553403,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}