{"id":"W2809249042","doi":"10.1016/j.stemcr.2018.05.018","title":"Disruption of GRIN2B Impairs Differentiation in Human Neurons","year":2018,"lang":"en","type":"article","venue":"Stem Cell Reports","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; Douglas Mental Health University Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Government of Jiangxi Province","keywords":"Biology; Missense mutation; Mutation; Glutamate receptor; NMDA receptor; Transcriptome; Receptor; Cell biology; Cellular differentiation; Neuroscience; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001213068,0.0002545155,0.0001676414,0.0001919107,0.00008956908,0.0001874468,0.0001576449,0.0002516233,0.0009931396],"category_scores_gemma":[0.000145161,0.00009902139,0.0001575342,0.0001049476,0.0001616299,0.00007910583,0.0002101715,0.0002759607,0.0004172088],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001684045,"about_ca_system_score_gemma":0.0001405778,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001112097,"about_ca_topic_score_gemma":0.001291165,"domain_scores_codex":[0.9999106,0.000013033,0.00001110155,0.00001812562,0.00002788178,0.00001921145],"domain_scores_gemma":[0.9999452,0.00001034025,0.00001357857,0.000007670935,0.000004247142,0.00001889808],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000705666,0.00002224485,0.0002641927,0.00001566544,0.000004712201,0.0001723907,0.00001841121,0.00008920548,0.9983389,0.00005935173,0.00003438013,0.0009099515],"study_design_scores_gemma":[0.00003518318,0.0005443075,0.01262309,0.00001258229,0.00002207685,0.002162768,0.00007620521,0.001477089,0.9802859,0.0001540172,0.002601099,0.000005778583],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976048,0.0005145271,0.0007775824,0.00004316068,0.00001072766,0.00000764404,0.0002746516,0.00004883862,0.000718025],"genre_scores_gemma":[0.9975115,0.0004224675,0.000740415,0.00002836204,0.000001477025,0.00001183475,0.0003486684,0.00001572835,0.0009195987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001112097,"threshold_uncertainty_score":0.003322363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04705825828154693,"score_gpt":0.3428111125505603,"score_spread":0.2957528542690134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}