{"id":"W2809263650","doi":"10.1371/journal.pbio.2004049","title":"Reporters to mark and eliminate basal or luminal epithelial cells in culture and in vivo","year":2018,"lang":"en","type":"article","venue":"PLoS Biology","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Tufts University School of Medicine; University of Toronto; National Cancer Institute; Cancer Research UK; National Institutes of Health; Campbell Family Institute for Breast Cancer Research; Breast Cancer Research Foundation","keywords":"Biology; Keratin 14; Keratin; Cell culture; Cancer research; Reporter gene; Metastasis; In vivo; Keratin 5; Cell biology; Suicide gene; Transgene; Molecular biology; Genetically modified mouse; Cancer; Gene expression; Gene; Genetic enhancement; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001462947,0.00009436357,0.0002581278,0.0001050089,0.00001560371,0.000004463532,0.0000285763,0.00009137375,0.0001756429],"category_scores_gemma":[0.00006368836,0.00006474296,0.00001463993,0.000112707,0.0001307416,0.000016474,0.00004670733,0.00009567555,0.000007257383],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002691014,"about_ca_system_score_gemma":0.00003654906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002280774,"about_ca_topic_score_gemma":0.001235893,"domain_scores_codex":[0.9992625,0.00003542873,0.0001838704,0.0002749438,0.00004003875,0.0002032502],"domain_scores_gemma":[0.9997019,0.00002600682,0.00003646527,0.0001098165,0.00002654535,0.00009924217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00236072,0.0001166181,0.04408769,0.00009256457,0.00003017539,0.000280025,0.001587302,8.180354e-8,0.9406821,0.00001274585,0.002574272,0.008175716],"study_design_scores_gemma":[0.005532825,0.004966612,0.1014281,0.0003010885,0.0001659819,0.0003699999,0.001110535,0.00008653997,0.6530678,0.0001977386,0.2323256,0.0004471936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971828,0.00014816,0.000007292978,0.0008209988,0.0001800181,0.0002303848,0.00003089368,0.000007283188,0.001392104],"genre_scores_gemma":[0.9955121,0.0003314583,0.001052495,0.001269661,0.0002751533,0.0000169793,0.000003680347,0.000008738178,0.001529707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2876143,"threshold_uncertainty_score":0.2640141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02099659503925883,"score_gpt":0.2873905666171233,"score_spread":0.2663939715778645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}