{"id":"W2809282651","doi":"10.1073/pnas.1719266115","title":"Human induced pluripotent stem cell-derived glial cells and neural progenitors display divergent responses to Zika and dengue infections","year":2018,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Mental Health; National Cancer Institute; National Institutes of Health; Simons Foundation; Association Européenne contre les Leucodystrophies; Emerald Foundation; National Alliance for Research on Schizophrenia and Depression; National Institute of Allergy and Infectious Diseases; Howard Hughes Medical Institute; Biogen; International Rett Syndrome Foundation; Simons Foundation Autism Research Initiative","keywords":"Zika virus; Induced pluripotent stem cell; Microcephaly; Biology; Dengue virus; Neural stem cell; Dengue fever; Progenitor cell; Immune system; Immunology; Virology; Innate immune system; Microglia; Stem cell; Virus; Neuroscience; Cell biology; Embryonic stem cell; Inflammation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000176672,0.0001569378,0.0001992137,0.0002907576,0.0001348403,0.0003152568,0.00008967763,0.0002002018,0.0006572098],"category_scores_gemma":[0.0002286978,0.0001493172,0.0002352847,0.0002553412,0.0001555445,0.0001577121,0.000198525,0.0004087094,0.0002076082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001092761,"about_ca_system_score_gemma":0.0001251358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004166226,"about_ca_topic_score_gemma":0.0004232049,"domain_scores_codex":[0.9998003,0.00002753809,0.00003824007,0.0000303799,0.00006100347,0.0000426132],"domain_scores_gemma":[0.9998893,0.00003076474,0.00002030325,0.00001255757,0.00002367762,0.00002344334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003801738,0.00003829594,0.005536817,0.00008093021,0.00002558364,0.0002681502,0.0002468485,0.0001602463,0.9888846,0.0003100024,0.00007934444,0.00398909],"study_design_scores_gemma":[0.00006814724,0.001840418,0.2001398,0.00004558361,0.0001908035,0.003126815,0.0009999182,0.002274674,0.7827307,0.0006084856,0.007937174,0.00003751999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960846,0.001101494,0.001009977,0.00003487936,0.00001768964,0.0000244689,0.0006335402,0.00001499289,0.001078406],"genre_scores_gemma":[0.9951184,0.00108962,0.0009513386,0.00009092985,0.00001065991,0.00007337513,0.001679087,0.000008390926,0.0009782441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006572098,"threshold_uncertainty_score":0.002198577,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03595812725531829,"score_gpt":0.3146727052216456,"score_spread":0.2787145779663273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}