{"id":"W2809289196","doi":"10.1111/hepr.13206","title":"Spermine oxidase is upregulated and promotes tumor growth in hepatocellular carcinoma","year":2018,"lang":"en","type":"article","venue":"Hepatology Research","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University Health Network","funders":"Science and Technology Commission of Shanghai Municipality; National Natural Science Foundation of China","keywords":"Cancer research; Downregulation and upregulation; Apoptosis; Gene knockdown; Chemistry; Cell growth; Cell cycle; Kinase; Oncogene; Hepatocellular carcinoma; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00045249,0.0001317057,0.0001842125,0.0001654484,0.0001405242,0.00001895186,0.0002371726,0.0001516908,0.00006529895],"category_scores_gemma":[0.0002692994,0.0001237094,0.00003002044,0.0003516863,0.0007322713,0.000004650075,0.0002968567,0.0001871796,0.00006133362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009636896,"about_ca_system_score_gemma":0.0001209454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000317938,"about_ca_topic_score_gemma":0.00009776343,"domain_scores_codex":[0.9984572,0.0001893115,0.0001972516,0.0005129919,0.0001443924,0.000498865],"domain_scores_gemma":[0.9991671,0.00004137579,0.0000294448,0.0004004602,0.0002303993,0.0001312285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000625363,0.00009733412,0.426433,0.00002547934,0.00001099171,0.00003624107,0.0001333588,7.136082e-9,0.5692069,0.0005896289,0.002980286,0.0004242182],"study_design_scores_gemma":[0.0006923769,0.0002302447,0.04660707,0.000007826691,0.000007769662,0.0001395479,0.00005666054,0.001142666,0.9385427,0.001080128,0.01131875,0.0001742829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960237,0.001264188,0.00003092879,0.001476662,0.00002978425,0.0003463566,0.00002277806,0.0000103881,0.0007952616],"genre_scores_gemma":[0.9982645,0.0001100133,0.0002035796,0.0002539389,0.0001788575,0.00009007379,0.00005277133,0.00002072855,0.0008255562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3798259,"threshold_uncertainty_score":0.5044721,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03561591555887261,"score_gpt":0.3285236617254921,"score_spread":0.2929077461666195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}