{"id":"W2809289196","doi":"10.1111/hepr.13206","title":"Spermine oxidase is upregulated and promotes tumor growth in hepatocellular carcinoma","year":2018,"lang":"en","type":"article","venue":"Hepatology Research","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Western Hospital; University Health Network","funders":"Science and Technology Commission of Shanghai Municipality; National Natural Science Foundation of China","keywords":"Cancer research; Downregulation and upregulation; Apoptosis; Gene knockdown; Chemistry; Cell growth; Cell cycle; Kinase; Oncogene; Hepatocellular carcinoma; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001462785,0.000235082,0.0001742492,0.0003856132,0.0001468167,0.000206271,0.00009441903,0.0001418795,0.001101858],"category_scores_gemma":[0.0001264078,0.00009992574,0.0001830731,0.0003108362,0.0001583056,0.0001362815,0.0001822088,0.0002052594,0.0002106015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002026012,"about_ca_system_score_gemma":0.0001388575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003754699,"about_ca_topic_score_gemma":0.0003801073,"domain_scores_codex":[0.9999355,0.000009956451,0.000006776746,0.00001321319,0.00002142035,0.00001310893],"domain_scores_gemma":[0.9998974,0.00001444935,0.00004677234,0.000004759686,0.00001636458,0.00002033108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007914265,0.00005652665,0.04103345,0.0002001685,0.00003827849,0.0006041199,0.00006610828,0.00008410806,0.9500403,0.0000983685,0.0001274565,0.006859671],"study_design_scores_gemma":[0.00006401261,0.001038966,0.5299828,0.00002576091,0.0001577419,0.002368939,0.0002056134,0.002387884,0.4585796,0.0002048617,0.004970661,0.00001307877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942379,0.003434844,0.001219353,0.00005961795,0.00002078763,0.00001678147,0.0001719228,0.00008437229,0.0007543854],"genre_scores_gemma":[0.997565,0.0009930107,0.0003843522,0.00001613922,0.00001621311,0.00001412321,0.0002396836,0.000004858032,0.000766592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001101858,"threshold_uncertainty_score":0.00368607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03561591555887261,"score_gpt":0.3285236617254921,"score_spread":0.2929077461666195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}