{"id":"W2809322172","doi":"10.1093/neuonc/noy059.289","title":"HGG-17. TUMOR MUTATIONAL BURDEN ANALYSIS OF PEDIATRIC TUMORS PROVIDES A DIAGNOSTIC TOOL FOR GERMLINE REPLICATION REPAIR DEFICIENCY AND PREDICT RESPONSE TO IMMUNE CHECKPOINT INHIBITION","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Children's Hospital; Hospital for Sick Children","funders":"","keywords":"Somatic hypermutation; Germline; Germline mutation; Mutation; Cancer research; DNA mismatch repair; Biology; Exome sequencing; Medicine; Genetics; DNA repair; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003465246,0.0002404019,0.0003546365,0.0006786137,0.0001396516,0.0003525088,0.0001643513,0.0001843434,0.001670273],"category_scores_gemma":[0.0006013823,0.0001207463,0.0002198079,0.0007238597,0.0001641806,0.0001504557,0.0002266742,0.0002455658,0.0003162363],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003133197,"about_ca_system_score_gemma":0.0002928952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002008645,"about_ca_topic_score_gemma":0.003453978,"domain_scores_codex":[0.9998221,0.00003286897,0.00001336386,0.0000508903,0.00004754644,0.00003324786],"domain_scores_gemma":[0.9995471,0.00008109459,0.00020136,0.00003527064,0.00004982608,0.00008533489],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000901403,0.00003008907,0.9255114,0.00006020073,0.000101468,0.0002764007,0.00006170257,0.0006987108,0.04279513,0.00009478875,0.001053506,0.02841514],"study_design_scores_gemma":[0.00003180471,0.0003296924,0.9794087,0.00001087166,0.00006856668,0.001386313,0.00004605822,0.001334381,0.01460958,0.0001222019,0.002646642,0.00000531543],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932715,0.0007411754,0.0009107745,0.00006114094,0.000005541391,0.00002648025,0.003957783,0.00006742566,0.0009581338],"genre_scores_gemma":[0.9918349,0.0003635316,0.002281335,0.00005273234,0.000007505215,0.00003503216,0.004911453,0.00003345644,0.0004801927],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002008645,"threshold_uncertainty_score":0.005587637,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01607914381849092,"score_gpt":0.3048965562310968,"score_spread":0.2888174124126059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}