{"id":"W2809361179","doi":"10.1016/j.abb.2018.06.008","title":"Mutational analysis of state-dependent contacts in the pore module of eukaryotic sodium channels","year":2018,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Neurobiology and Insect Physiology Research","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Federal Agency for Scientific Organizations; Russian Foundation for Basic Research","keywords":"Gating; Mutation; Alanine; Sodium channel; Tyrosine; Biophysics; Chemistry; Biology; Sodium; Amino acid; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008667427,0.00008073657,0.0002123501,0.0000838681,0.00004377971,0.000003301331,0.0002565645,0.00003276004,0.000007433972],"category_scores_gemma":[0.00008266597,0.00005753299,0.00007315109,0.0003523062,0.001302905,0.00003320423,0.00008078584,0.0001095981,4.735516e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001517348,"about_ca_system_score_gemma":0.00003784582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001723603,"about_ca_topic_score_gemma":0.000001663217,"domain_scores_codex":[0.9992175,0.0001100886,0.0002068014,0.0002142665,0.0001145704,0.000136802],"domain_scores_gemma":[0.9991404,0.0004757354,0.0001400059,0.0001910673,0.00002973446,0.00002308373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001863093,0.0001864654,0.001665804,0.00005467609,0.00004834216,0.000003973663,0.000718539,0.00003192518,0.9964499,0.0004164914,0.000002867562,0.0002347282],"study_design_scores_gemma":[0.0002047149,0.0002201789,0.02563752,0.00001278994,0.00003278866,0.000003336347,0.00008122112,0.0008652325,0.968706,0.004186686,5.33326e-7,0.00004904164],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991533,0.0000155392,0.00002430915,0.00006308401,0.0000205496,0.00007037287,0.0001235228,0.000002472241,0.0005268048],"genre_scores_gemma":[0.9997799,0.00003148917,0.00001702945,0.00006764299,0.00002314926,0.000003174132,0.00002559313,0.000002754753,0.00004929713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02774392,"threshold_uncertainty_score":0.4800609,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01936554764463412,"score_gpt":0.2734558394370112,"score_spread":0.2540902917923771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}