{"id":"W2809443411","doi":"10.1039/c8ra03908a","title":"Effective carrier-free gene-silencing activity of cholesterol-modified siRNAs","year":2018,"lang":"en","type":"article","venue":"RSC Advances","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University; Lakeridge Health","funders":"Natural Sciences and Engineering Research Council of Canada; Royal Society of Chemistry; Royal Society","keywords":"Small interfering RNA; Gene silencing; RNA interference; Trans-acting siRNA; Computational biology; Chemistry; Gene; RNA; Cell biology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003111843,0.000429063,0.0003109596,0.0002330432,0.0001664435,0.0002597254,0.0002883438,0.0003692817,0.001016997],"category_scores_gemma":[0.0002530015,0.0001545101,0.0002701725,0.0002319101,0.0002475808,0.0002219196,0.0001649838,0.000367243,0.0004201008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004761536,"about_ca_system_score_gemma":0.0003488867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001666569,"about_ca_topic_score_gemma":0.002418232,"domain_scores_codex":[0.9997544,0.00003627668,0.00003373786,0.00004750347,0.00008831546,0.00003980162],"domain_scores_gemma":[0.9998465,0.00004232905,0.00003622986,0.00001986511,0.00003597936,0.00001908386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001651828,0.000004554322,0.0000175935,0.00001776055,0.000002025464,0.00001377237,0.000008426187,0.0000238256,0.9995203,0.0000412958,0.00001651803,0.0003173815],"study_design_scores_gemma":[0.00000213713,0.00003014473,0.0002593683,9.040199e-7,0.000004712615,0.00002404272,0.000001633231,0.0002172146,0.9990753,0.000004514637,0.0003782241,0.000001752734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.982446,0.001373042,0.01170562,0.00007726263,0.0000378232,0.0001005115,0.0005456616,0.0002502956,0.003463898],"genre_scores_gemma":[0.9880441,0.0006987017,0.005778884,0.00003439453,0.000007276348,0.00008949178,0.000916537,0.0000514063,0.004379174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001666569,"threshold_uncertainty_score":0.003454745,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01002283632898043,"score_gpt":0.2708445092581078,"score_spread":0.2608216729291273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}