{"id":"W2809448137","doi":"10.1016/j.cyto.2018.06.006","title":"IL-15 and IFN-γ signal through the ERK pathway to inhibit HCV replication, independent of type I IFN signaling","year":2018,"lang":"en","type":"article","venue":"Cytokine","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Memorial University of Newfoundland; University Health Network; McMaster University Medical Centre","funders":"Canadian Institutes of Health Research","keywords":"Hepatitis C virus; Interferon; MAPK/ERK pathway; Viral replication; Virology; Immunology; Hepatitis C; Biology; Signal transduction; Virus; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002635201,0.0003113728,0.0002392914,0.0001753067,0.0001300634,0.0003839775,0.0001690022,0.0002141718,0.001818707],"category_scores_gemma":[0.0001867396,0.0001284567,0.0003734106,0.00009447143,0.000248752,0.0002792658,0.0002856552,0.0007422246,0.0004391565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003208089,"about_ca_system_score_gemma":0.0004684238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004225834,"about_ca_topic_score_gemma":0.0009915559,"domain_scores_codex":[0.9997708,0.00004630934,0.00002146901,0.0000189347,0.00004636135,0.00009614306],"domain_scores_gemma":[0.9999226,0.00001230066,0.00001967969,0.00001412634,0.00001074188,0.0000205744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001992061,0.0002153178,0.001038176,0.0001335155,0.000039971,0.0001049731,0.00002892265,0.0004763789,0.9856852,0.001163804,0.0002733727,0.008848314],"study_design_scores_gemma":[0.0002121636,0.0006571827,0.007607069,0.00002075185,0.00004650786,0.0003482881,0.00005134443,0.002683707,0.9826384,0.0004060159,0.005320569,0.00000802989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861763,0.003753358,0.003059422,0.0003956619,0.0001687931,0.00005834181,0.0003424675,0.00007506927,0.005970553],"genre_scores_gemma":[0.995582,0.000733525,0.0009447304,0.00006790269,0.00001532504,0.00002293184,0.0001672899,0.000006226797,0.002460016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001818707,"threshold_uncertainty_score":0.006084204,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01939896123035133,"score_gpt":0.2544104804114738,"score_spread":0.2350115191811225,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}