{"id":"W2809482891","doi":"10.1016/j.canlet.2018.06.021","title":"Agave negatively regulates YAP and TAZ transcriptionally and post-translationally in osteosarcoma cell lines","year":2018,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Juravinski Cancer Centre","funders":"Fondazione Italiana per la Ricerca sul Cancro; Aboca S.p.A. Società Agricola; Associazione Italiana per la Ricerca sul Cancro","keywords":"Agave; Osteosarcoma; Apoptosis; Cisplatin; Cell culture; Transcription factor; Cancer research; Biology; Viability assay; Cell biology; Chemistry; Chemotherapy; Biochemistry; Botany; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000817807,0.0002134345,0.0002385458,0.0001832287,0.0001520846,0.0002532184,0.0001215127,0.0001872323,0.0009282857],"category_scores_gemma":[0.0001041183,0.0001160797,0.0002784989,0.0001552177,0.0002257013,0.0001909804,0.0001525629,0.000466155,0.0002665467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001675149,"about_ca_system_score_gemma":0.0001429641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005308643,"about_ca_topic_score_gemma":0.001063184,"domain_scores_codex":[0.9999123,0.0000134321,0.00001054322,0.00001753496,0.00002821097,0.00001804287],"domain_scores_gemma":[0.9999301,0.00001647896,0.0000201419,0.00000875504,0.00001136897,0.00001312033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006873076,0.00001896875,0.0001271484,0.0000180861,0.000002799228,0.0000253638,0.00001090081,0.00002054783,0.9992394,0.00003577306,0.00001944747,0.0004128381],"study_design_scores_gemma":[0.00001047381,0.0001717604,0.006659952,0.000003327665,0.00001366267,0.0001346112,0.0000359392,0.0007303614,0.9900219,0.00005084175,0.002163374,0.000003750507],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942505,0.001665818,0.002312158,0.0001037418,0.00002670191,0.00001353169,0.0003412311,0.00005797182,0.001228344],"genre_scores_gemma":[0.9940481,0.0009668667,0.001433304,0.00005838871,0.000009607386,0.00002886831,0.0008573725,0.00001837668,0.002578988],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009282857,"threshold_uncertainty_score":0.003105402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007757158652275986,"score_gpt":0.227906528273495,"score_spread":0.220149369621219,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}