{"id":"W2809486037","doi":"10.1038/s41598-018-28070-0","title":"Granzyme B is elevated in autoimmune blistering diseases and cleaves key anchoring proteins of the dermal-epidermal junction","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Autoimmune Bullous Skin Diseases","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"International Collaboration On Repair Discoveries; Spinal Cord Injury BC; University of British Columbia","funders":"Canadian Institutes of Health Research; International Collaboration on Repair Discoveries; Albert-Ludwigs-Universität Freiburg; Health Canada; Canada Research Chairs; Michael Smith Health Research BC; University of Alberta; Rick Hansen Institute","keywords":"Dermis; Basement membrane; Granzyme B; Epidermolysis bullosa; Granzyme; Medicine; Papillary dermis; Dermatitis herpetiformis; Epidermolysis bullosa acquisita; Immunology; Pathology; Chemistry; Immune system; Bullous pemphigoid; Perforin; T cell; Antibody; CD8","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002043931,0.0004727424,0.0002830858,0.0009743511,0.0001717128,0.0004369459,0.0001232407,0.0004496301,0.001549546],"category_scores_gemma":[0.0003757347,0.0001889994,0.0002637611,0.0005365289,0.0002389266,0.0002306283,0.0002923925,0.0005239292,0.0003308197],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001660388,"about_ca_system_score_gemma":0.0000886796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002582579,"about_ca_topic_score_gemma":0.0001601863,"domain_scores_codex":[0.9997599,0.00004260181,0.00003251228,0.00007034738,0.00006130631,0.00003340619],"domain_scores_gemma":[0.9997452,0.00002840586,0.0001404438,0.00001997195,0.00002551138,0.00004057059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001598762,0.00007780817,0.03796536,0.0002555618,0.0001417385,0.001726111,0.0001442701,0.00006242119,0.9458728,0.0001301122,0.0002286923,0.01179641],"study_design_scores_gemma":[0.0001238804,0.001258484,0.6537533,0.00006971349,0.0003307773,0.01919932,0.0003775237,0.0007539857,0.31074,0.0007739231,0.01259103,0.00002808027],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867005,0.009637778,0.001916051,0.00009524271,0.00004303324,0.00002965568,0.0003704446,0.00009997432,0.001107296],"genre_scores_gemma":[0.9956428,0.002003744,0.0008790216,0.00006757819,0.00002373152,0.00001670992,0.0003120135,0.00001275205,0.001041576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001549546,"threshold_uncertainty_score":0.005183756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01389970604657133,"score_gpt":0.2521934427328421,"score_spread":0.2382937366862707,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}