{"id":"W2809506570","doi":"10.15698/mic2018.07.638","title":"Methodologies for in vitro and in vivo evaluation of efficacy of antifungal and antibiofilm agents and surface coatings against fungal biofilms","year":2018,"lang":"en","type":"review","venue":"Microbial Cell","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; Canada Research Chairs; University of Toronto","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Medical Research Council; National Institutes of Health; Israel Science Foundation; Deutsche Forschungsgemeinschaft; National Institute of Dental and Craniofacial Research; University of Aberdeen; Fonds Wetenschappelijk Onderzoek; Medical Research Council Centre for Medical Mycology; Amplyx; Wellcome Trust; Agence Nationale de la Recherche; Cidara Therapeutics; Astellas Pharma; Gilead Sciences; Pfizer","keywords":"Biofilm; Antifungal; Microbiology; Antifungal drugs; In vivo; Drug resistance; Echinocandins; Biology; Medicine; Fluconazole; Bacteria; Biotechnology; Caspofungin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.003489198,0.00033842,0.001956656,0.0002270274,0.00003539578,0.00001456261,0.00009184407,0.0003986662,0.00001269498],"category_scores_gemma":[0.0008556483,0.00028525,0.0001649104,0.0002582594,0.0004058705,0.0000590578,0.0001114798,0.000240715,5.100543e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000745976,"about_ca_system_score_gemma":0.0002784701,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006933949,"about_ca_topic_score_gemma":0.00006804338,"domain_scores_codex":[0.9974238,0.0005254723,0.0009353819,0.0006102673,0.0002186419,0.0002863912],"domain_scores_gemma":[0.9981694,0.0007759299,0.0005083146,0.0002721121,0.0002104922,0.00006373839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0013526,0.0003047657,0.006417336,0.05523066,0.00007314623,0.000007347432,0.0004651453,0.000001096777,0.8354014,0.000001325534,0.0005996245,0.1001456],"study_design_scores_gemma":[0.0215491,0.001700539,0.02823305,0.04231851,0.00500179,0.00005798031,0.0009447495,0.0004099798,0.8586391,0.00003901067,0.03938529,0.001720857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5635137,0.4347654,0.000008274591,0.000005247436,0.00005259176,0.001387506,0.0001985395,0.000004945032,0.00006381017],"genre_scores_gemma":[0.1807418,0.8143423,0.004602706,0.00001815976,0.00003835315,0.00000712674,0.0001106405,0.00003471207,0.0001041583],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.3827718,"threshold_uncertainty_score":0.9999599,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1318144063453495,"score_gpt":0.3983011493737132,"score_spread":0.2664867430283637,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}