{"id":"W2809612791","doi":"10.1093/neuonc/noy059.387","title":"LGG-46. TRAMETINIB THERAPY IN PEDIATRIC PATIENTS WITH LOW-GRADE GLIOMAS (LGG) WITH BRAF GENE FUSION; A DISEASE-SPECIFIC COHORT IN THE FIRST PEDIATRIC TESTING OF TRAMETINIB","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medicine; Trametinib; Rash; Cohort; Internal medicine; Adverse effect; Oncology; Pediatrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004559783,0.0004018758,0.0007322329,0.0001901833,0.0002802684,0.0005611457,0.0002056242,0.0003039133,0.0008021895],"category_scores_gemma":[0.0003793779,0.0001904814,0.0005239208,0.0003551196,0.0002781551,0.0002858352,0.0002697334,0.0008110193,0.0002745141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006501172,"about_ca_system_score_gemma":0.001027507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001523406,"about_ca_topic_score_gemma":0.005515119,"domain_scores_codex":[0.999803,0.00006291543,0.00001184261,0.00004265052,0.00002922005,0.00005046375],"domain_scores_gemma":[0.9997573,0.000021281,0.00006165119,0.00001656233,0.00002096836,0.0001222655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.06822077,0.004076926,0.6449232,0.0004526025,0.0008121888,0.00528435,0.0007168997,0.003666641,0.07980642,0.0004613779,0.01333029,0.1782483],"study_design_scores_gemma":[0.0196298,0.107434,0.7919716,0.0001236035,0.001025971,0.01775402,0.0005062349,0.003638015,0.02397507,0.0004419464,0.03343926,0.00006046472],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961266,0.0009327275,0.0002633632,0.0001613939,0.000009964128,0.0002858895,0.001178532,0.00004395407,0.0009975296],"genre_scores_gemma":[0.9944999,0.0007912727,0.001151487,0.0003404231,0.00002231575,0.0002430707,0.002430753,0.00001873667,0.0005021296],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001523406,"threshold_uncertainty_score":0.004716992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0235252672558584,"score_gpt":0.2617352856153456,"score_spread":0.2382100183594872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}