{"id":"W2809612791","doi":"10.1093/neuonc/noy059.387","title":"LGG-46. TRAMETINIB THERAPY IN PEDIATRIC PATIENTS WITH LOW-GRADE GLIOMAS (LGG) WITH BRAF GENE FUSION; A DISEASE-SPECIFIC COHORT IN THE FIRST PEDIATRIC TESTING OF TRAMETINIB","year":2018,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Medicine; Trametinib; Rash; Cohort; Internal medicine; Adverse effect; Oncology; Pediatrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004130552,0.000410883,0.0007588641,0.0006627399,0.0001252742,0.00002391551,0.0002962317,0.0001720947,0.00006333258],"category_scores_gemma":[0.0002806758,0.0002449944,0.0001051442,0.002511004,0.0002492362,0.00007756198,0.00005110935,0.0004041934,0.00001671701],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001568141,"about_ca_system_score_gemma":0.0003711073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009058925,"about_ca_topic_score_gemma":0.0003009166,"domain_scores_codex":[0.9969354,0.0003111136,0.000711792,0.0007616395,0.0006646562,0.0006154179],"domain_scores_gemma":[0.9968618,0.00160337,0.0004108349,0.0006419825,0.0002543417,0.0002276788],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00189153,0.007416075,0.9797074,0.00006250724,0.00003340558,0.00102732,0.0007929321,0.00003580244,0.0005864255,0.000008872816,0.0003482785,0.008089472],"study_design_scores_gemma":[0.01494229,0.01190917,0.9694846,0.00004274941,0.000272995,0.00005928528,0.00009337738,0.00004996325,0.0005668396,0.00001431526,0.002334776,0.0002296482],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947249,0.0007919494,0.000002768283,0.001429831,0.0001604353,0.00251047,0.00002824955,0.00004713751,0.0003042676],"genre_scores_gemma":[0.9969181,0.0006936243,0.0006572519,0.0007696087,0.0004317561,0.0004205397,0.00003960186,0.00006827628,0.000001183966],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01305076,"threshold_uncertainty_score":0.9990581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0235252672558584,"score_gpt":0.2617352856153456,"score_spread":0.2382100183594872,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}