{"id":"W2809631602","doi":"10.1161/atvbaha.118.311238","title":"Diabetic Vascular Calcification Mediated by the Collagen Receptor Discoidin Domain Receptor 1 via the Phosphoinositide 3-Kinase/Akt/Runt-Related Transcription Factor 2 Signaling Axis","year":2018,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Cell Adhesion Molecules Research","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ted Rogers Centre for Heart Research","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Banting and Best Diabetes Centre, University of Toronto; National Institute of Dental and Craniofacial Research; Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"DDR1; RUNX2; Vascular smooth muscle; Biology; Discoidin domain; Endocrinology; Internal medicine; Protein kinase B; Cancer research; Cell biology; Osteoblast; Signal transduction; Medicine; Receptor tyrosine kinase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001888461,0.00050439,0.0002701975,0.0003628944,0.0002004056,0.0003416602,0.0002712373,0.0002476254,0.001180707],"category_scores_gemma":[0.0000976555,0.0002237696,0.0003927959,0.000175631,0.0002679285,0.0002395726,0.00025084,0.0006043573,0.0003229038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003167514,"about_ca_system_score_gemma":0.0002425118,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005464801,"about_ca_topic_score_gemma":0.001015089,"domain_scores_codex":[0.9997955,0.00002590645,0.00001707327,0.00004426574,0.00006759884,0.0000496757],"domain_scores_gemma":[0.9999011,0.000006285446,0.00004502936,0.000008906301,0.000009523807,0.00002919448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001728588,0.00002601603,0.000517908,0.00006624016,0.000007355414,0.0001570022,0.00001478522,0.00004922841,0.9978824,0.0001880091,0.00008543385,0.0008327002],"study_design_scores_gemma":[0.0001715178,0.0005896075,0.03272989,0.00003712317,0.0001012933,0.001991868,0.0001607474,0.002986324,0.9539163,0.0002969571,0.006995221,0.00002315767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870256,0.004226849,0.003975685,0.0003706992,0.0001090194,0.00003483411,0.000562635,0.0001664003,0.003528285],"genre_scores_gemma":[0.9914762,0.002043077,0.00263203,0.00009869799,0.00003154104,0.00004533356,0.0004474553,0.00001393479,0.003211632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001180707,"threshold_uncertainty_score":0.003949881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02733590139472039,"score_gpt":0.2790148754198802,"score_spread":0.2516789740251598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}