{"id":"W2809644342","doi":"10.1101/352559","title":"Cancer stemness, intratumoral heterogeneity, and immune response across cancers","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; BC Children's Hospital; University of British Columbia","funders":"","keywords":"Biology; Immune system; Cancer stem cell; Cancer research; Cancer; Stem cell; Tumor progression; Phenotype; Cancer cell; Tumor microenvironment; Transcriptome; Immunology; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004717006,0.0001292377,0.0002991691,0.0009303719,0.0001540603,0.0005658247,0.0001071355,0.0001838724,0.001020206],"category_scores_gemma":[0.000720654,0.00007723724,0.0001319836,0.0005722378,0.0004107371,0.0003140928,0.0003955173,0.0004232902,0.0001632829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002410227,"about_ca_system_score_gemma":0.0001744605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002199102,"about_ca_topic_score_gemma":0.0002458493,"domain_scores_codex":[0.999721,0.00005759141,0.0000195373,0.00007868736,0.00008412417,0.0000390028],"domain_scores_gemma":[0.9992473,0.0001817531,0.0003406253,0.0000624475,0.00007484058,0.00009302732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000626888,0.00008142254,0.4282137,0.0001676026,0.0001842876,0.0001474047,0.0002838626,0.001567157,0.5399624,0.00107273,0.000400304,0.02729238],"study_design_scores_gemma":[0.00001448781,0.0003875834,0.8942633,0.00001865169,0.0001217273,0.001081731,0.0004175447,0.004033755,0.09479405,0.002218315,0.002634471,0.00001437824],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970035,0.000827571,0.001325267,0.00007049808,0.000004011304,0.000006981075,0.0002699431,0.00002760769,0.0004645499],"genre_scores_gemma":[0.9990326,0.0001350657,0.0004337081,0.00003430799,0.000007470382,0.000007357412,0.0002137553,0.000007395054,0.0001282273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001020206,"threshold_uncertainty_score":0.003412902,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01974265339892695,"score_gpt":0.2846974147210584,"score_spread":0.2649547613221315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}