{"id":"W2809644342","doi":"10.1101/352559","title":"Cancer stemness, intratumoral heterogeneity, and immune response across cancers","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria; BC Children's Hospital; University of British Columbia","funders":"","keywords":"Biology; Immune system; Cancer stem cell; Cancer research; Cancer; Stem cell; Tumor progression; Phenotype; Cancer cell; Tumor microenvironment; Transcriptome; Immunology; Gene expression; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001350964,0.0007786138,0.00106598,0.0002020572,0.0003158168,0.0002646028,0.000418436,0.0007277346,0.0001288873],"category_scores_gemma":[0.0001127646,0.0007628911,0.0002798011,0.0004934202,0.0007464324,0.0001467998,0.0006274183,0.0008794624,0.00002066615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001342956,"about_ca_system_score_gemma":0.002355252,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001368474,"about_ca_topic_score_gemma":0.00009420378,"domain_scores_codex":[0.9962902,0.0002386839,0.000775466,0.001279532,0.0005175125,0.0008986153],"domain_scores_gemma":[0.9968907,0.00006616591,0.0005232579,0.001536483,0.0005789917,0.0004044196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01006672,0.000113939,0.03651355,0.0009499711,0.0009961143,0.0001754474,0.00005786452,0.000005240038,0.9499977,0.000009177173,0.001089669,0.00002463179],"study_design_scores_gemma":[0.002530464,0.0002970052,0.5917206,0.001588175,0.0002376622,2.976646e-7,0.000009138867,0.00007471307,0.3911617,5.238753e-7,0.01157249,0.0008072754],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9714456,0.02290424,0.00004317108,0.0008932551,0.002566357,0.001114661,0.0007130138,0.0003150813,0.000004685596],"genre_scores_gemma":[0.9932407,0.00374884,0.0005911948,0.0007811156,0.0009839556,0.0004317728,7.627121e-7,0.0001939601,0.00002771169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.558836,"threshold_uncertainty_score":0.9994822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01974265339892695,"score_gpt":0.2846974147210584,"score_spread":0.2649547613221315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}