{"id":"W2809649199","doi":"10.1016/j.joca.2018.06.002","title":"Low back pain and disc degeneration are decreased following chronic toll-like receptor 4 inhibition in a mouse model","year":2018,"lang":"en","type":"article","venue":"Osteoarthritis and Cartilage","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"Shriners Hospitals for Children - Canada; Montreal Children's Hospital; McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research","keywords":"TLR4; Medicine; Chronic pain; Endocrinology; Internal medicine; Glial fibrillary acidic protein; In vivo; Inflammation; Pathology; Biology; Immunohistochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004669636,0.001371683,0.0008203552,0.002107807,0.0004939874,0.0008464891,0.0007925655,0.001532025,0.003541537],"category_scores_gemma":[0.0002493716,0.0007378134,0.001138902,0.0005945128,0.001269273,0.0008292494,0.000375289,0.002715448,0.0008923574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005730101,"about_ca_system_score_gemma":0.0006382515,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001082394,"about_ca_topic_score_gemma":0.002099057,"domain_scores_codex":[0.999411,0.00006625234,0.0000697479,0.0001288398,0.0001537192,0.0001705604],"domain_scores_gemma":[0.9993206,0.00003563894,0.0002997288,0.00005341198,0.00005453056,0.0002360705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002004806,0.0004865235,0.000452932,0.0001226006,0.00004123493,0.0002419489,0.0000322432,0.00009304238,0.9947078,0.000235234,0.0002219595,0.001359702],"study_design_scores_gemma":[0.001038508,0.005687019,0.02235599,0.0001147524,0.0004755019,0.002179461,0.0003929507,0.002515838,0.9579775,0.0006534822,0.006534046,0.00007486336],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885916,0.002804887,0.004057371,0.0008132199,0.0002443211,0.00008426005,0.001802568,0.0003477539,0.001253992],"genre_scores_gemma":[0.9746742,0.003336483,0.004600422,0.0004630721,0.00009484634,0.0004769017,0.002031107,0.0001136227,0.01420935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003541537,"threshold_uncertainty_score":0.01184762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01133794030063883,"score_gpt":0.2401015983260928,"score_spread":0.228763658025454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}