{"id":"W2809738299","doi":"10.1101/361139","title":"A phenotypic small-molecule screen identifies halogenated salicylanilides as inhibitors of fungal morphogenesis, biofilm formation and host cell invasion","year":2018,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Université Laval; Audrey and Theodor Geisel School of Medicine at Dartmouth; Dartmouth College; Centre Hospitalier Universitaire de Québec; Fondation CHU de Québec","keywords":"Niclosamide; Candida albicans; Biology; Biofilm; Corpus albicans; Yeast; Microbiology; Pathogenic fungus; Biochemistry; Bacteria; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001091678,0.0004310739,0.0002909545,0.0004449541,0.0001363585,0.0001872403,0.000207659,0.0002140638,0.001523089],"category_scores_gemma":[0.0001199415,0.0001409249,0.0002698108,0.0002543498,0.0001273118,0.0001027957,0.0001788135,0.0002084337,0.0002943661],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001384004,"about_ca_system_score_gemma":0.0001633126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005628206,"about_ca_topic_score_gemma":0.001445829,"domain_scores_codex":[0.9998869,0.00001698782,0.000008017701,0.00001826683,0.00004964633,0.00002014558],"domain_scores_gemma":[0.9999125,0.00001921134,0.00001899942,0.00000796046,0.00002111074,0.00002032678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008642265,0.00006688607,0.000300811,0.00004478757,0.000009919378,0.00004995266,0.000006301364,0.0001415303,0.9967348,0.00002559065,0.00004286379,0.002490264],"study_design_scores_gemma":[0.00005425781,0.002272981,0.00599223,0.00001292715,0.00004232709,0.0002527694,0.00002637212,0.0009417554,0.9882398,0.00002711487,0.002129288,0.000008123282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914324,0.002048685,0.002307882,0.00009160805,0.00002150733,0.0001540462,0.001051893,0.0001173575,0.002774533],"genre_scores_gemma":[0.9909869,0.001769072,0.00271324,0.00007459103,0.00001081108,0.0000733555,0.001412431,0.00001955182,0.002940004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001523089,"threshold_uncertainty_score":0.005095184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01690637025420872,"score_gpt":0.2290486100191109,"score_spread":0.2121422397649022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}