{"id":"W2809797363","doi":"10.1016/j.chembiol.2018.05.014","title":"Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death","year":2018,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; Hospital for Sick Children; University of Regina; University of Toronto","funders":"Janssen Canada; Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Pfizer; Natural Sciences and Engineering Research Council of Canada; Innovative Medicines Initiative; Pfizer Canada; Ontario Genomics Institute; Global Affairs Canada; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ontario Ministry of Economic Development and Innovation; Saskatchewan Health Research Foundation; Innovative Medicines Canada; Wellcome Trust; Institute of Infection and Immunity; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Boehringer Ingelheim; AbbVie; Novartis Pharma; Canada Foundation for Innovation; University of Toronto; Takeda Pharmaceutical Company; Canadian Institutes of Health Research; Wellcome","keywords":"Apoptosis; Protease; Cell biology; Programmed cell death; Mitochondrion; Cell; Chemistry; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001204182,0.0003286147,0.0003297932,0.0000639278,0.0001688889,0.00002317423,0.0002444992,0.0006789145,0.0001986078],"category_scores_gemma":[0.0001108761,0.0002998678,0.0001226782,0.00009187695,0.0005656718,0.00000573259,0.0002744664,0.0002640736,0.0001337135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002155444,"about_ca_system_score_gemma":0.00006173179,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004415447,"about_ca_topic_score_gemma":0.00002095114,"domain_scores_codex":[0.9980112,0.000191603,0.0003070425,0.0008920319,0.00007416276,0.0005239748],"domain_scores_gemma":[0.9988985,0.00003218652,0.0001536588,0.0005382758,0.0001044085,0.0002729379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003796994,0.0001353132,0.001639208,0.00002512077,0.00002922258,0.000006155756,0.00002705303,3.079462e-7,0.9949694,0.0001092328,0.00240305,0.0002761838],"study_design_scores_gemma":[0.001457155,0.0008506739,0.0002785022,0.000004912054,0.00005480315,0.00002784392,0.0000076372,0.00001601088,0.9732439,0.0004142998,0.02329584,0.0003484137],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941862,0.0001817172,0.001339432,0.0000897212,0.000731423,0.000400175,0.00003660989,0.00004209037,0.002992683],"genre_scores_gemma":[0.9933599,0.00005036741,0.00217931,0.0004449309,0.002210503,0.0000507643,0.0002990743,0.00003590275,0.001369237],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02172555,"threshold_uncertainty_score":0.9999453,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01626944436410224,"score_gpt":0.262938318882952,"score_spread":0.2466688745188498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}