{"id":"W2809797363","doi":"10.1016/j.chembiol.2018.05.014","title":"Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell Death","year":2018,"lang":"en","type":"article","venue":"Cell chemical biology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":111,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; Princess Margaret Cancer Centre; Hospital for Sick Children; University of Regina; University of Toronto","funders":"Janssen Canada; Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Pfizer; Natural Sciences and Engineering Research Council of Canada; Innovative Medicines Initiative; Pfizer Canada; Ontario Genomics Institute; Global Affairs Canada; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ontario Ministry of Economic Development and Innovation; Saskatchewan Health Research Foundation; Innovative Medicines Canada; Wellcome Trust; Institute of Infection and Immunity; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo; Genome Canada; Boehringer Ingelheim; AbbVie; Novartis Pharma; Canada Foundation for Innovation; University of Toronto; Takeda Pharmaceutical Company; Canadian Institutes of Health Research; Wellcome","keywords":"Apoptosis; Protease; Cell biology; Programmed cell death; Mitochondrion; Cell; Chemistry; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001634491,0.000416887,0.0002684437,0.0001801896,0.0001568229,0.0002795116,0.000189914,0.0003722092,0.001473787],"category_scores_gemma":[0.0002000615,0.0001583175,0.0002253815,0.0002012091,0.0002150839,0.0002522788,0.0001529629,0.0005141498,0.0004243331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003792967,"about_ca_system_score_gemma":0.0001690578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004723746,"about_ca_topic_score_gemma":0.000804604,"domain_scores_codex":[0.9998318,0.00003108572,0.00002235432,0.00002848536,0.00004008771,0.00004615986],"domain_scores_gemma":[0.9998679,0.00003808623,0.00003695512,0.00001798117,0.00001091493,0.00002809309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006530582,0.0000564264,0.0001191113,0.00002227375,0.00001268347,0.000141927,0.00001296589,0.0001156939,0.9976961,0.00009618145,0.00006880501,0.00100467],"study_design_scores_gemma":[0.00007642715,0.0007104688,0.001346077,0.00000217838,0.00002011264,0.0003902221,0.0000228261,0.000430963,0.996036,0.00004918711,0.0009111592,0.000004425452],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972414,0.000792339,0.000833987,0.00005995393,0.00003131256,0.00002293617,0.0002358081,0.00003741913,0.0007448769],"genre_scores_gemma":[0.9973391,0.0005123709,0.0005795141,0.00004733378,0.00001263701,0.00002316426,0.0004532284,0.0000139106,0.001018799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001473787,"threshold_uncertainty_score":0.004930317,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01626944436410224,"score_gpt":0.262938318882952,"score_spread":0.2466688745188498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}