{"id":"W2809946846","doi":"10.1038/s41401-018-0013-y","title":"Effects of SLCO1B1 and GATM gene variants on rosuvastatin-induced myopathy are unrelated to high plasma exposure of rosuvastatin and its metabolites","year":2018,"lang":"en","type":"article","venue":"Acta Pharmacologica Sinica","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Natural Science Foundation of China","keywords":"SLCO1B1; Rosuvastatin; Single-nucleotide polymorphism; Internal medicine; Atorvastatin; Pharmacogenetics; Medicine; Rosuvastatin Calcium; Pharmacology; Endocrinology; Statin; Chemistry; Biology; Genetics; Gene; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008673982,0.0003140047,0.001057558,0.000159212,0.0001217138,0.00001411796,0.0001390432,0.0001994561,0.00009353786],"category_scores_gemma":[0.0009406012,0.0002358594,0.0001358568,0.0004058915,0.0001316124,0.00008276484,0.0001526028,0.0002895891,0.000009853679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002728646,"about_ca_system_score_gemma":0.000139401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005598924,"about_ca_topic_score_gemma":0.000002847034,"domain_scores_codex":[0.9975173,0.0004273908,0.0006086295,0.0005740632,0.000459692,0.0004128844],"domain_scores_gemma":[0.9978701,0.0006385891,0.0003725238,0.0003412946,0.0003643369,0.0004131436],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001306487,0.0005316579,0.0009998676,0.0005008104,0.0006133901,0.00008553475,0.0005016102,0.000001596375,0.9794532,0.00008842918,0.0003534513,0.01556397],"study_design_scores_gemma":[0.006181973,0.004845242,0.2470063,0.0002326976,0.0006772428,0.00004534132,0.00006570692,0.00008882747,0.7399161,0.00002861544,0.0007060137,0.0002058862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953272,0.001669057,0.00001208994,0.0008377928,0.0002782133,0.001598367,0.00007770044,0.00005474091,0.0001448904],"genre_scores_gemma":[0.9960666,0.001138102,0.001281769,0.00109663,0.000238928,0.00007521663,0.00001163513,0.00003742314,0.0000536708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2460065,"threshold_uncertainty_score":0.9618065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02015118167435124,"score_gpt":0.2921524325191914,"score_spread":0.2720012508448401,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}