{"id":"W2809971493","doi":"10.1371/journal.pone.0199156","title":"Activation of Th2 cells downregulates CRTh2 through an NFAT1 mediated mechanism","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Alberta","funders":"Institute of Circulatory and Respiratory Health; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Canadian Lung Association; GlaxoSmithKline","keywords":"NFAT; GATA3; Transcription factor; Cell biology; Flow cytometry; HEK 293 cells; Biology; Downregulation and upregulation; Chemistry; Receptor; Molecular biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001604545,0.0004918756,0.000252415,0.0001921245,0.0001913707,0.0003238864,0.0001259656,0.0002223854,0.002761163],"category_scores_gemma":[0.00008367442,0.0001186296,0.0004144248,0.0001247499,0.0002273735,0.0001574505,0.000189786,0.0005796816,0.0005136423],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002762793,"about_ca_system_score_gemma":0.0001537077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004205291,"about_ca_topic_score_gemma":0.0006010265,"domain_scores_codex":[0.9997924,0.00003806926,0.00001280479,0.00004768274,0.00005231125,0.00005680591],"domain_scores_gemma":[0.9999124,0.00001399072,0.00002460009,0.00001485557,0.00001620073,0.00001802969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001077253,0.00002032876,0.0002014984,0.00005109285,0.000005076591,0.00005064909,0.00001201054,0.00002412701,0.9988711,0.00003726569,0.00004028259,0.0005787622],"study_design_scores_gemma":[0.00005148196,0.0003591101,0.01516037,0.00001740748,0.000027158,0.0003633846,0.00004643894,0.0005954414,0.9781672,0.00006151573,0.005145465,0.000004970806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851683,0.006218459,0.003677166,0.0002041543,0.0001178723,0.000076702,0.0008830397,0.000148465,0.003505694],"genre_scores_gemma":[0.9885142,0.002344347,0.002636974,0.0001178742,0.00008135181,0.0001116676,0.0009195499,0.00002389402,0.005250087],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002761163,"threshold_uncertainty_score":0.009236991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04338823469748627,"score_gpt":0.2203604097813797,"score_spread":0.1769721750838934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}