{"id":"W2809971493","doi":"10.1371/journal.pone.0199156","title":"Activation of Th2 cells downregulates CRTh2 through an NFAT1 mediated mechanism","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"IL-33, ST2, and ILC Pathways","field":"Immunology and Microbiology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Alberta","funders":"Institute of Circulatory and Respiratory Health; Canadian Institutes of Health Research; Fondation pour la Recherche Médicale; Canadian Lung Association; GlaxoSmithKline","keywords":"NFAT; GATA3; Transcription factor; Cell biology; Flow cytometry; HEK 293 cells; Biology; Downregulation and upregulation; Chemistry; Receptor; Molecular biology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001419014,0.0001622267,0.0003147865,0.00006785805,0.0001537935,0.000007236939,0.0001996739,0.0003127455,0.0006896656],"category_scores_gemma":[0.00009048649,0.0001441944,0.00004330349,0.0001608243,0.0002336603,0.0002853874,0.00005350467,0.0001615904,0.0008353447],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002026191,"about_ca_system_score_gemma":0.00005370335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001690761,"about_ca_topic_score_gemma":0.00003815869,"domain_scores_codex":[0.9989657,0.0001336185,0.0002658995,0.0002684889,0.0000669454,0.0002992993],"domain_scores_gemma":[0.9991297,0.00009272979,0.0001631469,0.0003507758,0.0002429513,0.00002072893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001162544,0.0009187268,0.00005084127,0.00003882259,0.0002682747,5.134778e-7,0.002005339,1.833028e-7,0.9925102,0.003545459,0.0004187362,0.000126623],"study_design_scores_gemma":[0.0007499899,0.0007246163,0.0006550955,0.00007748202,0.00008082568,0.000001570283,0.0002074636,0.00001111089,0.9923639,0.003312627,0.001649185,0.0001661689],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994137,0.00007099639,0.0002400315,0.00008224134,0.0002269164,0.0002397906,0.0004811801,0.0001203973,0.004401411],"genre_scores_gemma":[0.9974269,0.0001145226,0.000963499,0.0001695522,0.0001193334,0.00001236265,0.0003409745,0.00002088974,0.0008319356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003569475,"threshold_uncertainty_score":0.9999426,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04338823469748627,"score_gpt":0.2203604097813797,"score_spread":0.1769721750838934,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}