{"id":"W2810015216","doi":"10.1158/1538-7445.am2018-5531","title":"Abstract 5531: Detection of co-occurring and potential resistance mutations in cell-free, circulating tumor DNA from patients with <i>BRAF</i> <i>mutant</i> metastatic melanoma undergoing treatment with BRAF-targeted therapies","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Genomics","funders":"","keywords":"Digital polymerase chain reaction; Neuroblastoma RAS viral oncogene homolog; Multiplex; V600E; Medicine; Melanoma; Cancer research; Vemurafenib; Mutation; Oncology; Molecular biology; Internal medicine; Cancer; KRAS; Biology; Metastatic melanoma; Polymerase chain reaction; Bioinformatics; Gene; Genetics; Colorectal cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003659741,0.0002494013,0.0002234343,0.0006361009,0.0002130665,0.0004279446,0.0001511831,0.0003833221,0.001790051],"category_scores_gemma":[0.001461461,0.0001578442,0.0001064197,0.0003455916,0.0001708716,0.0001675692,0.0001541805,0.0002391525,0.0004176238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001929186,"about_ca_system_score_gemma":0.0001239954,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006668345,"about_ca_topic_score_gemma":0.0007315672,"domain_scores_codex":[0.9995365,0.00008060428,0.00005021864,0.0001814752,0.0001078167,0.00004339637],"domain_scores_gemma":[0.9993334,0.0002384127,0.0001658024,0.00004570702,0.0001202484,0.00009632571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001362806,0.00025121,0.4500009,0.0001146894,0.00005845799,0.0007839754,0.0004979866,0.0002564979,0.5221544,0.0000629813,0.0005607941,0.02389528],"study_design_scores_gemma":[0.0001158111,0.00357396,0.7165555,0.00003351766,0.0001069087,0.007834488,0.0003807669,0.003751912,0.2635704,0.00007110821,0.003981613,0.00002406669],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975103,0.0003330029,0.001199741,0.00003490188,0.00001120209,0.00002900446,0.0004464872,0.0000471748,0.0003881868],"genre_scores_gemma":[0.9957352,0.00008476255,0.002832867,0.00007237069,0.00001062612,0.00002790461,0.0007179757,0.000009231707,0.0005089339],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001790051,"threshold_uncertainty_score":0.0059883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570874581996937,"score_gpt":0.2840320830942377,"score_spread":0.2683233372742683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}