{"id":"W2810064376","doi":"10.1016/j.ymthe.2018.05.026","title":"RTN4 Knockdown Dysregulates the AKT Pathway, Destabilizes the Cytoskeleton, and Enhances Paclitaxel-Induced Cytotoxicity in Cancers","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"Izaak Walton Killam Health Centre; Dalhousie University","funders":"Canadian Institutes of Health Research; Nova Scotia Health Research Foundation; National Cancer Institute; Beatrice Hunter Cancer Research Institute","keywords":"Protein kinase B; Gene knockdown; PI3K/AKT/mTOR pathway; Cancer research; Carcinogenesis; Biology; Cancer cell; Cell biology; Cancer; Signal transduction; Cell culture","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009570141,0.0003327321,0.0002152298,0.0004361473,0.0003000589,0.0003181321,0.0002520949,0.0002770427,0.003025685],"category_scores_gemma":[0.00009091252,0.0001670131,0.0003198162,0.0002126551,0.000224974,0.0002800326,0.0001648371,0.0004598682,0.0005635851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000714968,"about_ca_system_score_gemma":0.0003990881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001981724,"about_ca_topic_score_gemma":0.003109283,"domain_scores_codex":[0.9998982,0.00001198164,0.000009948049,0.00001912095,0.00002861397,0.00003218199],"domain_scores_gemma":[0.9999543,0.000004268255,0.00001405354,0.000006283323,0.000007542289,0.00001349036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000297243,0.00009249498,0.0003919137,0.00006200717,0.0000206892,0.00007045819,0.00001065823,0.0002949948,0.9943936,0.0003376948,0.0003478382,0.003680277],"study_design_scores_gemma":[0.00004809189,0.0002306613,0.005713832,0.00001122678,0.00005952959,0.0002648419,0.00003464296,0.002253799,0.9843146,0.000150568,0.00690976,0.000008543715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903352,0.002203477,0.001735632,0.0002681865,0.00007857601,0.00002466754,0.0006038376,0.0002133838,0.004536973],"genre_scores_gemma":[0.9895524,0.001469693,0.001092081,0.00006295306,0.00001005962,0.00004431308,0.0006845495,0.00004050145,0.007043463],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003025685,"threshold_uncertainty_score":0.01012188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009326066836217626,"score_gpt":0.2479052492253087,"score_spread":0.2385791823890911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}