{"id":"W2810096032","doi":"10.1186/s12916-018-1096-5","title":"Optimising first- and second-line treatment strategies for untreated major depressive disorder — the SUN☺D study: a pragmatic, multi-centre, assessor-blinded randomised controlled trial","year":2018,"lang":"en","type":"article","venue":"BMC Medicine","topic":"Treatment of Major Depression","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Novartis Pharma; Astellas Pharma; Shionogi; Eisai; Pfizer; Daiichi-Sankyo; GlaxoSmithKline; AstraZeneca; Ministry of Health, Labour and Welfare; Eli Lilly and Company","keywords":"Medicine; Sertraline; Mirtazapine; Depression (economics); Confidence interval; Major depressive disorder; Patient Health Questionnaire; Antidepressant; Randomized controlled trial; Guideline; Major depressive episode; Depressive symptoms; Internal medicine; Psychiatry; Physical therapy; Mood; Cognition","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009949097,0.0006586883,0.0019316,0.0002381049,0.0005755998,0.00009982541,0.0001896184,0.0001974258,0.0005966942],"category_scores_gemma":[0.002429284,0.0003155801,0.0002467078,0.000255162,0.0004432849,0.0001802432,0.0000682281,0.0001765305,0.00001004086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001467871,"about_ca_system_score_gemma":0.0003527821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002922208,"about_ca_topic_score_gemma":0.003636529,"domain_scores_codex":[0.9963683,0.0004717862,0.00116579,0.0007956925,0.0006263062,0.0005721586],"domain_scores_gemma":[0.9940004,0.003737572,0.0006358153,0.0008390894,0.0004746769,0.0003124346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9635186,0.007393318,0.01256594,0.0002466227,0.00280145,0.00006745575,0.007460332,0.00005944656,0.001044004,0.000055849,0.0009972214,0.003789787],"study_design_scores_gemma":[0.9562972,0.01253065,0.004255699,0.0004017719,0.004922465,0.00003023914,0.007458886,0.01258641,0.0004999025,0.0000753919,0.000666222,0.0002752306],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.955611,0.002212967,0.005281112,0.002932919,0.0005446817,0.03262985,0.00002910767,0.0001923958,0.0005659655],"genre_scores_gemma":[0.9895177,0.00008400633,0.003014111,0.0001776662,0.001135852,0.002828692,0.0001334114,0.00008580105,0.003022791],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03390667,"threshold_uncertainty_score":0.9999296,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05707029083232866,"score_gpt":0.3561332540340502,"score_spread":0.2990629632017215,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}