{"id":"W2810223831","doi":"10.1074/jbc.ra118.002728","title":"Peptide-based sequestration of the adaptor protein Nck1 in pancreatic β cells enhances insulin biogenesis and protects against diabetogenic stresses","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Clinical Research Institute; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Government of Canada","keywords":"Signal transducing adaptor protein; Cell biology; Unfolded protein response; Protein kinase B; Endoplasmic reticulum; Signal transduction; Cancer research; Chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001255498,0.0003272288,0.0003093728,0.0001029114,0.0001423133,0.0002650068,0.0002435192,0.0002251079,0.0007564278],"category_scores_gemma":[0.00009825884,0.00009630534,0.0001843203,0.0001343896,0.0001931036,0.0001929497,0.0001973101,0.0005211917,0.0002659028],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003261788,"about_ca_system_score_gemma":0.0002135106,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000311882,"about_ca_topic_score_gemma":0.0003237033,"domain_scores_codex":[0.9998852,0.00001466242,0.00001491151,0.0000326653,0.00002645246,0.00002607921],"domain_scores_gemma":[0.9999104,0.00001008348,0.00003229164,0.00001244804,0.000008503484,0.00002638127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001302528,0.00002533668,0.0000851984,0.00002944869,0.000003588348,0.00001856364,0.000004556627,0.00006896787,0.9990767,0.00003006909,0.00001212173,0.0005151332],"study_design_scores_gemma":[0.00001923994,0.0002626737,0.001584769,0.000002921321,0.00001315705,0.000103018,0.00000872766,0.0006097328,0.9965484,0.00001422607,0.0008293524,0.000003793494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968883,0.0008447492,0.001564862,0.00005671999,0.0000238518,0.00001565921,0.0001212107,0.00003771058,0.0004468164],"genre_scores_gemma":[0.9962113,0.0005854694,0.001958583,0.00004844812,0.00000693758,0.00002392859,0.000289487,0.00001261334,0.0008632468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007564278,"threshold_uncertainty_score":0.002530575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02169066591067369,"score_gpt":0.2420595748963544,"score_spread":0.2203689089856807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}