{"id":"W2810273617","doi":"10.1136/esmoopen-2018-eacr25.400","title":"PO-372 Investigating the epigenetic changes underlying combination treatment of acute promyelocytic leukaemia with all-trans retinoic acid and arsenic trioxide","year":2018,"lang":"en","type":"article","venue":"ESMO Open","topic":"Retinoids in leukemia and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"","keywords":"Arsenic trioxide; Acute promyelocytic leukemia; Retinoic acid; Epigenetics; Arsenic; Cancer research; Tretinoin; Medicine; Chemistry; Biochemistry; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002012137,0.0001891365,0.0002010217,0.00002719669,0.0001814769,0.00007192264,0.0003237832,0.0001088683,0.0000121191],"category_scores_gemma":[0.00002716315,0.0001243504,0.00003233447,0.0001138401,0.0003958999,0.000009735324,0.0001068462,0.00006028582,0.000001963304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003881239,"about_ca_system_score_gemma":0.0001933628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001436707,"about_ca_topic_score_gemma":0.0003773857,"domain_scores_codex":[0.9990073,0.00009984926,0.0001882624,0.0003535409,0.0001290287,0.0002219476],"domain_scores_gemma":[0.9993059,0.00002229289,0.0001621605,0.0003515166,0.00009478192,0.00006333812],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002736495,0.00009347334,0.00562819,0.00008928376,0.0005090979,0.000008241947,0.002137542,0.000007745782,0.9742098,0.0001508023,0.0001070589,0.01678512],"study_design_scores_gemma":[0.001356336,0.00266246,0.005000541,0.00006981997,0.0001963923,0.00005086899,0.0003059689,0.00006787465,0.9876229,0.0003102442,0.002171885,0.0001846679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961972,0.0006613536,0.0005340731,0.000702715,0.00004190084,0.0007196425,0.000006331657,0.000009117915,0.001127647],"genre_scores_gemma":[0.9971192,0.0006703941,0.001208406,0.0001675574,0.00006844906,0.0001050967,0.0000702682,0.00002660462,0.0005639582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01660045,"threshold_uncertainty_score":0.5070862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0391299488620396,"score_gpt":0.304446273711356,"score_spread":0.2653163248493164,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}