{"id":"W2810290010","doi":"10.1002/jbmr.3475","title":"A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Trial Evaluating the Efficacy of Burosumab, an Anti-FGF23 Antibody, in Adults With X-Linked Hypophosphatemia: Week 24 Primary Analysis","year":2018,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":340,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Kyowa Hakko Kirin; Ultragenyx Pharmaceutical","keywords":"Hypophosphatemia; Placebo; Medicine; WOMAC; Internal medicine; Osteomalacia; Gastroenterology; Placebo-controlled study; Osteoarthritis; Surgery; Double blind; Vitamin D and neurology; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001864946,0.001652477,0.003679469,0.0005323024,0.0005974774,0.0009844407,0.001078295,0.002123032,0.005998112],"category_scores_gemma":[0.001855562,0.0007223189,0.002200278,0.0004004929,0.001073672,0.001103185,0.0003718749,0.002693189,0.0009719122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005395262,"about_ca_system_score_gemma":0.001093043,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001146836,"about_ca_topic_score_gemma":0.002892106,"domain_scores_codex":[0.9992844,0.0003672449,0.00004078899,0.0001309143,0.00005879505,0.0001178816],"domain_scores_gemma":[0.9990577,0.0002794457,0.0002175815,0.00006824399,0.0000858491,0.0002911203],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.978192,0.005371481,0.0003795261,0.0007279048,0.0008640807,0.0000426942,0.00005540531,0.0002209438,0.003107494,0.00005806316,0.0006993525,0.01028104],"study_design_scores_gemma":[0.9365768,0.06049309,0.001629091,0.00003304957,0.0003067053,0.00002217215,0.00001980834,0.0002056055,0.0002746815,0.0000874421,0.000338842,0.00001271525],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9787776,0.008366592,0.001223267,0.0006167308,0.0004972795,0.006702637,0.001655472,0.0003036998,0.001856703],"genre_scores_gemma":[0.9796954,0.003350765,0.00242119,0.001155551,0.0002910544,0.009033389,0.001001716,0.00004632318,0.003004561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005998112,"threshold_uncertainty_score":0.02006567,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1118705389074112,"score_gpt":0.4582421274353874,"score_spread":0.3463715885279762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}