{"id":"W2810295565","doi":"10.1021/acs.molpharmaceut.8b00392","title":"Positron-Emission Tomography of HER2-Positive Breast Cancer Xenografts in Mice with <sup>89</sup>Zr-Labeled Trastuzumab-DM1: A Comparison with <sup>89</sup>Zr-Labeled Trastuzumab","year":2018,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Ontario Institute for Cancer Research; University of Toronto; Terry Fox Foundation","keywords":"Trastuzumab; Chemistry; Immunoconjugate; Positron emission tomography; Trastuzumab emtansine; Breast cancer; Nuclear medicine; Cancer; Medicine; Monoclonal antibody; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002418265,0.0004367522,0.0002858404,0.000228317,0.00007618191,0.0002185042,0.0002581016,0.0003440656,0.0008395287],"category_scores_gemma":[0.00009008424,0.0002212672,0.0001996604,0.0002225483,0.0001373948,0.0002386862,0.0001234142,0.0004918116,0.0002304157],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002498364,"about_ca_system_score_gemma":0.0001512414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009743102,"about_ca_topic_score_gemma":0.0009135155,"domain_scores_codex":[0.9999171,0.00001666163,0.000004129568,0.00002348008,0.00001595885,0.0000225651],"domain_scores_gemma":[0.9999583,0.000009179347,0.00001158301,0.000004704789,0.00000608184,0.00001017393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002545042,0.00002923499,0.0002023444,0.00003207861,0.000008019759,0.00004192203,0.00001533888,0.0001453183,0.9982253,0.0000633122,0.00003327539,0.0009493756],"study_design_scores_gemma":[0.00005223544,0.0009871061,0.004488365,0.000007136623,0.00005176823,0.0005943575,0.0000319037,0.002513612,0.988714,0.00003559414,0.002517311,0.000006594861],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859267,0.003406568,0.006490295,0.0001461584,0.00003093404,0.00004972204,0.0006955919,0.0001205097,0.003133461],"genre_scores_gemma":[0.9797199,0.003311779,0.009267953,0.00007822114,0.00001564825,0.00009728235,0.001264984,0.00008499542,0.00615913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009743102,"threshold_uncertainty_score":0.002808511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0236335417081599,"score_gpt":0.3611983093569542,"score_spread":0.3375647676487943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}