{"id":"W2810295565","doi":"10.1021/acs.molpharmaceut.8b00392","title":"Positron-Emission Tomography of HER2-Positive Breast Cancer Xenografts in Mice with <sup>89</sup>Zr-Labeled Trastuzumab-DM1: A Comparison with <sup>89</sup>Zr-Labeled Trastuzumab","year":2018,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"Ontario Institute for Cancer Research; University of Toronto; Terry Fox Foundation","keywords":"Trastuzumab; Chemistry; Immunoconjugate; Positron emission tomography; Trastuzumab emtansine; Breast cancer; Nuclear medicine; Cancer; Medicine; Monoclonal antibody; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008612386,0.001177325,0.001779589,0.00104192,0.0003132008,0.0001255085,0.0008391122,0.0004720658,0.0005088839],"category_scores_gemma":[0.0000517211,0.001001575,0.0003397923,0.003339216,0.001239952,0.0002801807,0.0002619114,0.001974745,0.00003776186],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001344476,"about_ca_system_score_gemma":0.001447506,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001511935,"about_ca_topic_score_gemma":0.000265988,"domain_scores_codex":[0.9915447,0.0007743998,0.001349133,0.001582125,0.00268172,0.002067911],"domain_scores_gemma":[0.9956666,0.0001861045,0.0004940529,0.001071597,0.001388912,0.001192747],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02993923,0.009756057,0.2265998,0.002871637,0.005101746,0.002539115,0.02004833,0.008573194,0.661679,0.00006942422,0.004529992,0.02829251],"study_design_scores_gemma":[0.03281611,0.00770925,0.01359498,0.005102818,0.002463349,0.001011167,0.002892341,0.08281327,0.8418306,0.00001930264,0.00774426,0.00200263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9874238,0.00337658,0.001751034,0.002010252,0.0001210067,0.003537994,0.0004527132,0.0002037428,0.00112289],"genre_scores_gemma":[0.9944725,0.0004547386,0.002476062,0.001122917,0.0003331082,0.0003593107,0.0002203781,0.000326975,0.0002340055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2130048,"threshold_uncertainty_score":0.9992434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0236335417081599,"score_gpt":0.3611983093569542,"score_spread":0.3375647676487943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}