{"id":"W2810371779","doi":"10.1136/esmoopen-2018-eacr25.720","title":"PO-202 PI3K activation in neural stem cells drives tumourigenesis which can be ameliorated by targeting the cAMP response element binding (CREB) protein","year":2018,"lang":"en","type":"article","venue":"ESMO Open","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"CREB; Neural stem cell; Element (criminal law); Neuroscience; Cell biology; Cancer research; Chemistry; Stem cell; Medicine; Biology; Biochemistry; Transcription factor; Political science; Gene; Law","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001698714,0.0005021818,0.0002266862,0.000334003,0.0001788671,0.0003303876,0.0004443814,0.0004770697,0.003361784],"category_scores_gemma":[0.00009319968,0.0002296288,0.0003204134,0.0002481447,0.0004793676,0.0002368601,0.0002704039,0.0009165835,0.0006505936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004474218,"about_ca_system_score_gemma":0.000441135,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001043722,"about_ca_topic_score_gemma":0.001446641,"domain_scores_codex":[0.9997035,0.0000304457,0.00003845968,0.00004500072,0.0001174918,0.00006507284],"domain_scores_gemma":[0.9998586,0.00002065525,0.00004347784,0.0000203694,0.000008298113,0.00004852497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001404798,0.00007338834,0.00007120155,0.00004521609,0.000004173628,0.00005734741,0.00001672737,0.00007604619,0.9983224,0.0002790513,0.00007348219,0.0008405469],"study_design_scores_gemma":[0.00002548448,0.000343232,0.001017509,0.000005314732,0.000009647371,0.0001202608,0.00002133755,0.0009909215,0.9947602,0.00006674771,0.002635937,0.000003407747],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894419,0.0007269828,0.003732291,0.0002122456,0.00009283817,0.0001064814,0.001064228,0.0003648713,0.004258262],"genre_scores_gemma":[0.9864776,0.0005287023,0.002785446,0.00006309458,0.00001328829,0.0001533103,0.001218798,0.0000491012,0.008710624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003361784,"threshold_uncertainty_score":0.01124632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0251261983150871,"score_gpt":0.2936227902761393,"score_spread":0.2684965919610522,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}