{"id":"W2810375766","doi":"10.1111/cbdd.13360","title":"Sinapic acid phenethyl ester as a potent selective 5‐lipoxygenase inhibitor: Synthesis and structure–activity relationship","year":2018,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Zileuton; Caffeic acid phenethyl ester; Chemistry; Arachidonate 5-lipoxygenase; Caffeic acid; Lipoxygenase; Cyclooxygenase; Moiety; Enzyme inhibitor; Catechol; Stereochemistry; IC50; Linker; Pharmacology; Biochemistry; Arachidonic acid; Enzyme; Antioxidant; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003231537,0.0003985544,0.0004947684,0.00004929988,0.0002389108,0.00004189126,0.0002715346,0.0006992054,0.0005894169],"category_scores_gemma":[0.002675425,0.000290809,0.0001286194,0.0001649186,0.0008960735,0.0001006898,0.0001768105,0.0005084999,0.00007919616],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001391724,"about_ca_system_score_gemma":0.00007190753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004949066,"about_ca_topic_score_gemma":0.00000589605,"domain_scores_codex":[0.9978284,0.0003023199,0.0002868997,0.0009228762,0.000129706,0.0005297897],"domain_scores_gemma":[0.9968992,0.002086626,0.0002871486,0.0003885691,0.0001097203,0.000228752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000399064,0.0001515168,0.007626729,0.00002064218,0.00007833886,0.000004371454,0.00008874548,1.189627e-7,0.9708254,0.00005999908,0.0003774539,0.02036762],"study_design_scores_gemma":[0.0002818414,0.00008004904,0.002433877,0.00002991731,0.00007259558,0.00003747686,0.00002821264,0.00007155869,0.9888419,0.007400781,0.0003376705,0.0003841171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965712,0.0002887163,0.0003302158,0.0005502003,0.00007903095,0.0001544754,0.00005781808,0.0001449701,0.001823395],"genre_scores_gemma":[0.9976766,0.00001979025,0.001314859,0.0001881685,0.0006061832,0.00005857457,0.00001626867,0.00002564623,0.00009389524],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0199835,"threshold_uncertainty_score":0.9999544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02361343224373513,"score_gpt":0.2480775814589316,"score_spread":0.2244641492151965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}