{"id":"W2810375766","doi":"10.1111/cbdd.13360","title":"Sinapic acid phenethyl ester as a potent selective 5‐lipoxygenase inhibitor: Synthesis and structure–activity relationship","year":2018,"lang":"en","type":"article","venue":"Chemical Biology & Drug Design","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Moncton","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Zileuton; Caffeic acid phenethyl ester; Chemistry; Arachidonate 5-lipoxygenase; Caffeic acid; Lipoxygenase; Cyclooxygenase; Moiety; Enzyme inhibitor; Catechol; Stereochemistry; IC50; Linker; Pharmacology; Biochemistry; Arachidonic acid; Enzyme; Antioxidant; In vitro; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001716923,0.0005748802,0.0003862175,0.0003708445,0.0001164617,0.0001655994,0.0003528651,0.0002978068,0.001787237],"category_scores_gemma":[0.00009078118,0.0001927939,0.0003214819,0.0003645571,0.0001833159,0.0002844911,0.0002391901,0.0005705446,0.0009399734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001678777,"about_ca_system_score_gemma":0.0002711626,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004577128,"about_ca_topic_score_gemma":0.001030936,"domain_scores_codex":[0.9999487,0.000007277435,0.00000476729,0.00001087483,0.00001448307,0.00001387023],"domain_scores_gemma":[0.9999434,0.000006382493,0.0000143251,0.000006828531,0.00001034896,0.00001874406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003126563,0.0002426893,0.000219309,0.0005605912,0.00003321608,0.0004978202,0.00003557491,0.0009767831,0.9723856,0.00034339,0.0002578887,0.02413446],"study_design_scores_gemma":[0.0003084298,0.006008233,0.005037867,0.00005468504,0.0001724219,0.0009639967,0.0000309929,0.001513294,0.9539488,0.0001911506,0.0317286,0.00004154097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8943787,0.0746027,0.0151759,0.000406508,0.0002270102,0.0006432221,0.001246318,0.0002181416,0.01310144],"genre_scores_gemma":[0.9445489,0.0388823,0.008640266,0.0002331798,0.0001105941,0.0001302877,0.00110467,0.00002682932,0.006322952],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001787237,"threshold_uncertainty_score":0.005978942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02361343224373513,"score_gpt":0.2480775814589316,"score_spread":0.2244641492151965,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}