{"id":"W2810399886","doi":"10.1016/j.phrs.2018.06.027","title":"Label-free cell signaling pathway deconvolution of angiotensin type 1 receptor reveals time-resolved G-protein activity and distinct AngII and AngIIIIV responses","year":2018,"lang":"en","type":"article","venue":"Pharmacological Research","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Angiotensin II; Receptor; Endogeny; Signal transduction; Cell biology; HEK 293 cells; G protein-coupled receptor; Chemistry; Cell type; G protein; Functional selectivity; Biology; Cell; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001371346,0.0002178157,0.0001986091,0.0001175861,0.0001516959,0.0003220282,0.0003370417,0.0003866149,0.00128876],"category_scores_gemma":[0.0001328539,0.0001366045,0.0001568564,0.0001212686,0.000223401,0.0002985747,0.0001655969,0.0006958927,0.0003624748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004515871,"about_ca_system_score_gemma":0.0003236496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001384273,"about_ca_topic_score_gemma":0.001976802,"domain_scores_codex":[0.9999336,0.000005280907,0.000001748534,0.00001476146,0.00002077031,0.00002378908],"domain_scores_gemma":[0.9999491,0.00001676583,0.0000085723,0.000007981915,0.000007909647,0.000009671667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005998847,0.00001176329,0.00006876092,0.00001194856,0.000002048115,0.00002292007,0.00001140461,0.0002204113,0.9980299,0.000328629,0.00005658255,0.00117569],"study_design_scores_gemma":[0.000009421292,0.00002641425,0.00156909,0.000001452602,0.000004465761,0.0000414438,0.00001375869,0.0108114,0.9866452,0.0001598468,0.0007110642,0.000006521061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.959166,0.0003894886,0.03710704,0.0002068655,0.00003181387,0.00001491323,0.000397245,0.000258085,0.002428603],"genre_scores_gemma":[0.9768033,0.00079303,0.01681844,0.0001099521,0.00001267666,0.00004659869,0.0004827101,0.0001073955,0.004825858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001384273,"threshold_uncertainty_score":0.004311383,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06984692852066239,"score_gpt":0.3616075175325956,"score_spread":0.2917605890119332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}