{"id":"W2810408973","doi":"10.1021/jacs.8b05807","title":"3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation","year":2018,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":146,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"H2020 Marie Skłodowska-Curie Actions; Biotechnology and Biological Sciences Research Council; Diamond Light Source; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; FP7 Ideas: European Research Council; Wellcome Trust; Wellcome","keywords":"Chemistry; Stereochemistry; Ubiquitin ligase; Peptidomimetic; Diastereomer; Stereoselectivity; Proline; Hydroxylation; Ubiquitin; Hydrogen bond; Amino acid; Molecule; Biochemistry; Peptide; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003213563,0.0003761843,0.0001502078,0.000167768,0.0001587338,0.0001773409,0.0003851336,0.000338736,0.001336714],"category_scores_gemma":[0.0002525852,0.0001323536,0.0002086172,0.0001390134,0.0002425842,0.0003494174,0.0001760856,0.0005531436,0.0004808371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000382768,"about_ca_system_score_gemma":0.000376446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006833558,"about_ca_topic_score_gemma":0.001159503,"domain_scores_codex":[0.9998529,0.00004038784,0.000006786223,0.00002361668,0.0000349711,0.00004131265],"domain_scores_gemma":[0.9998814,0.00002208062,0.00003828591,0.000016806,0.00001558156,0.00002578572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002671547,0.0000656037,0.0001893569,0.0001176116,0.0000102998,0.0001729964,0.00005399708,0.0008851861,0.9836926,0.001013004,0.0004474648,0.01308472],"study_design_scores_gemma":[0.0000269639,0.0003408917,0.0004308492,0.000004553379,0.000005234203,0.0003001672,0.00001046554,0.0005982625,0.9921704,0.00009683125,0.006001162,0.00001431612],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8924196,0.01146997,0.08171465,0.001010939,0.0002045673,0.0004202969,0.001553856,0.0004459471,0.0107602],"genre_scores_gemma":[0.9582444,0.004148852,0.03079696,0.0002593349,0.00003397943,0.00009771923,0.0008058302,0.00005968366,0.005553202],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001336714,"threshold_uncertainty_score":0.004471779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00802880347192571,"score_gpt":0.2438914239027392,"score_spread":0.2358626204308135,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}