{"id":"W2810456709","doi":"10.1158/1538-7445.am2018-ct046","title":"Abstract CT046: A phase I basket study of the PI3K inhibitor taselisib (GDC-0032) in <i>PIK3CA</i>-mutated locally advanced or metastatic solid tumors","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Tolerability; KRAS; Internal medicine; Clinical endpoint; Cancer; Oncology; Adverse effect; Colorectal cancer; Cancer research; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009335619,0.001709502,0.001523166,0.0005318332,0.0004617216,0.001126623,0.001137904,0.001073758,0.005332023],"category_scores_gemma":[0.0007112117,0.0005689714,0.001103248,0.0006774598,0.0007592085,0.0008233881,0.0004106804,0.003040777,0.001323163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001339624,"about_ca_system_score_gemma":0.002551688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002980357,"about_ca_topic_score_gemma":0.00583506,"domain_scores_codex":[0.9997448,0.0000957873,0.00001577034,0.00004923617,0.00003013339,0.00006422495],"domain_scores_gemma":[0.9995424,0.00004294855,0.00008405518,0.00003344428,0.00003699774,0.0002602765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6733714,0.07649181,0.009830013,0.001114652,0.001733718,0.0005577114,0.000308268,0.003923244,0.1150569,0.0006083835,0.01419855,0.1028054],"study_design_scores_gemma":[0.5455268,0.4274388,0.01154426,0.00004955703,0.000617257,0.0005517301,0.00008308854,0.001902138,0.008040318,0.0002127906,0.003990295,0.00004288083],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894881,0.001325791,0.0006866433,0.0004419001,0.000103596,0.002804509,0.002673296,0.0002015205,0.002274611],"genre_scores_gemma":[0.9816673,0.001792584,0.002171106,0.0009566008,0.0001279807,0.002985674,0.006508488,0.00006186587,0.003728329],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005332023,"threshold_uncertainty_score":0.01783741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09041560544615307,"score_gpt":0.477469590281986,"score_spread":0.387053984835833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}