{"id":"W2810456709","doi":"10.1158/1538-7445.am2018-ct046","title":"Abstract CT046: A phase I basket study of the PI3K inhibitor taselisib (GDC-0032) in <i>PIK3CA</i>-mutated locally advanced or metastatic solid tumors","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Tolerability; KRAS; Internal medicine; Clinical endpoint; Cancer; Oncology; Adverse effect; Colorectal cancer; Cancer research; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001499244,0.0003569635,0.0008256283,0.0004711221,0.0002371915,0.00003678718,0.0006138328,0.00007926222,0.001288365],"category_scores_gemma":[0.0007284643,0.0002301273,0.000107536,0.002575423,0.001032656,0.0002772288,0.0002572066,0.001049923,0.00003465731],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000682861,"about_ca_system_score_gemma":0.001885469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001630578,"about_ca_topic_score_gemma":0.005003737,"domain_scores_codex":[0.9951777,0.0004306228,0.0009076819,0.0007527014,0.00168322,0.001048115],"domain_scores_gemma":[0.9967213,0.0004064025,0.0002597201,0.001083744,0.001224561,0.0003042537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0617496,0.01430326,0.007234606,0.00139594,0.001039289,0.00138647,0.01918755,0.00121517,0.6516757,0.00003083884,0.004269334,0.2365123],"study_design_scores_gemma":[0.1236465,0.02381974,0.04178259,0.00694735,0.0003521377,0.0002020641,0.04948299,0.001149613,0.7372016,0.0006254407,0.01342668,0.001363273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938324,0.0008775415,0.00005457452,0.001034742,0.0002769668,0.003488606,0.0001256778,0.00005900758,0.0002504964],"genre_scores_gemma":[0.9972872,0.00008840018,0.0002633015,0.0003030618,0.0003623564,0.0008723594,0.0000109573,0.000100232,0.0007121224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.235149,"threshold_uncertainty_score":0.9996246,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09041560544615307,"score_gpt":0.477469590281986,"score_spread":0.387053984835833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}