{"id":"W2810487964","doi":"10.1016/j.ymthe.2018.06.002","title":"Global Transcriptional Response to CRISPR/Cas9-AAV6-Based Genome Editing in CD34+ Hematopoietic Stem and Progenitor Cells","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; Stanford Maternal and Child Health Research Institute; Amon G. Carter Foundation; Sundhed og Sygdom, Det Frie Forskningsråd; Children's Health Research Institute; National Heart, Lung, and Blood Institute; Natur og Univers, Det Frie Forskningsråd; National Institute of Allergy and Infectious Diseases; Stanford University","keywords":"Genome editing; Biology; Stem cell; Cas9; Cell biology; Haematopoiesis; RNA editing; Progenitor cell; Electroporation; CRISPR; Gene expression; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002677496,0.0002027053,0.0001525243,0.00006637732,0.00005621422,0.00003758207,0.0001558073,0.0001248277,0.00001755773],"category_scores_gemma":[0.00001255875,0.0002127125,0.00007597369,0.0001718728,0.00006300153,0.000002829382,0.00003270069,0.00005772213,0.00001109129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002905364,"about_ca_system_score_gemma":0.00006082629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009970053,"about_ca_topic_score_gemma":0.00001983869,"domain_scores_codex":[0.998789,0.0000972671,0.0002087652,0.0004144995,0.0001665314,0.0003240032],"domain_scores_gemma":[0.9994805,0.00000848973,0.0000279341,0.0002805608,0.00006664983,0.0001358708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005889336,0.00004807776,0.0005614894,0.00001347443,0.00002409181,0.00002152511,0.0001469863,0.0005859041,0.9965438,0.00001845071,0.00004680791,0.001400455],"study_design_scores_gemma":[0.001205566,0.0006382928,0.005267689,0.00002021154,0.000006700587,0.00002206487,0.00008295861,0.0002192934,0.971804,0.00002649984,0.02043348,0.0002732194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9293306,0.001852131,0.06785499,0.0003409514,0.0001771537,0.0003437568,0.00002721895,0.00001909688,0.00005409229],"genre_scores_gemma":[0.9962775,0.00002563411,0.00252967,0.0007786883,0.0002363323,0.0000533154,0.0000151668,0.00003157138,0.00005219488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06694681,"threshold_uncertainty_score":0.8674165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007751233009182189,"score_gpt":0.2819906133048418,"score_spread":0.2742393802956596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}