{"id":"W2810487964","doi":"10.1016/j.ymthe.2018.06.002","title":"Global Transcriptional Response to CRISPR/Cas9-AAV6-Based Genome Editing in CD34+ Hematopoietic Stem and Progenitor Cells","year":2018,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; Stanford Maternal and Child Health Research Institute; Amon G. Carter Foundation; Sundhed og Sygdom, Det Frie Forskningsråd; Children's Health Research Institute; National Heart, Lung, and Blood Institute; Natur og Univers, Det Frie Forskningsråd; National Institute of Allergy and Infectious Diseases; Stanford University","keywords":"Genome editing; Biology; Stem cell; Cas9; Cell biology; Haematopoiesis; RNA editing; Progenitor cell; Electroporation; CRISPR; Gene expression; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003338989,0.0002264108,0.000306667,0.0001950073,0.0001814115,0.0005176293,0.0002829914,0.0003397399,0.00311121],"category_scores_gemma":[0.0001586005,0.0001466033,0.0002741887,0.0001597647,0.0003424545,0.0001382078,0.0002626274,0.001107108,0.0005524931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003244572,"about_ca_system_score_gemma":0.0003222708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008009925,"about_ca_topic_score_gemma":0.001270257,"domain_scores_codex":[0.9995441,0.00005741863,0.00003959149,0.0001340803,0.0001203146,0.0001044916],"domain_scores_gemma":[0.9998482,0.00003596485,0.00003056019,0.00002096043,0.00001802819,0.00004628118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006353685,0.00001805706,0.00007988777,0.000009332371,0.000002147277,0.00001403575,0.000009209353,0.00007705531,0.9989699,0.0001388361,0.00005220336,0.0005656449],"study_design_scores_gemma":[0.000008909781,0.00006223587,0.001232576,0.000001639998,0.000006567048,0.00004642286,0.00001760876,0.0009322356,0.996659,0.00004830179,0.0009816429,0.000002801751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97921,0.000566671,0.01462386,0.0002428114,0.00009064972,0.00006115945,0.001162584,0.0004391767,0.003602961],"genre_scores_gemma":[0.989997,0.0001436311,0.003901476,0.00011106,0.000009847533,0.00003548835,0.0006799815,0.00006868091,0.005052859],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00311121,"threshold_uncertainty_score":0.01040804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007751233009182189,"score_gpt":0.2819906133048418,"score_spread":0.2742393802956596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}