{"id":"W2810557289","doi":"10.1016/j.celrep.2018.05.093","title":"A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Office of Research Infrastructure Programs, National Institutes of Health; Biotechnology and Biological Sciences Research Council; Medical Research Council; National Institutes of Health; National Centre for the Replacement Refinement and Reduction of Animals in Research; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Mauritius Research Council; Medical Research Council Canada; Wellcome Trust","keywords":"Proteostasis; Cell biology; Biology; Innate immune system; Transcription factor; Unfolded protein response; Signal transduction; Chaperone (clinical); Transmembrane protein; Heat shock protein; Biochemistry; Immunology; Immune system; Endoplasmic reticulum; Receptor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006722152,0.0002530732,0.0002258551,0.00006682595,0.0001948027,0.00005230833,0.0001130242,0.0002484174,0.000112319],"category_scores_gemma":[0.000162945,0.0002509936,0.0000771854,0.0001066643,0.0002838513,0.000005402845,0.00007037497,0.0001070819,0.00001481866],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001988872,"about_ca_system_score_gemma":0.0001983784,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002008466,"about_ca_topic_score_gemma":0.00001043062,"domain_scores_codex":[0.9982513,0.0001182227,0.0003985718,0.000648025,0.0002039883,0.0003799478],"domain_scores_gemma":[0.9989196,0.00002126204,0.0001840251,0.0005328619,0.0001494728,0.000192763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003243498,0.00006110509,0.0006432036,0.00003168694,0.00003161549,0.0001224225,0.00138267,0.00001362369,0.9968563,8.676504e-7,0.0002143251,0.000317788],"study_design_scores_gemma":[0.0004504827,0.0007673901,0.0008608258,0.00001421956,0.00005090969,0.0002172788,0.0001543369,0.00006278374,0.9850883,0.00006617777,0.01194867,0.0003186379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959635,0.001166911,0.001841991,0.0001588362,0.0002007331,0.0004035415,0.000006774363,0.00004152719,0.0002161661],"genre_scores_gemma":[0.9960556,0.000096465,0.001882632,0.00019304,0.000263982,0.00001658069,0.00007007489,0.00006039613,0.001361247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01176806,"threshold_uncertainty_score":0.9999942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007555148482673696,"score_gpt":0.2053453449855802,"score_spread":0.1977901965029065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}