{"id":"W2810557289","doi":"10.1016/j.celrep.2018.05.093","title":"A PQM-1-Mediated Response Triggers Transcellular Chaperone Signaling and Regulates Organismal Proteostasis","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Office of Research Infrastructure Programs, National Institutes of Health; Biotechnology and Biological Sciences Research Council; Medical Research Council; National Institutes of Health; National Centre for the Replacement Refinement and Reduction of Animals in Research; National Centre for the Replacement, Refinement and Reduction of Animals in Research; Mauritius Research Council; Medical Research Council Canada; Wellcome Trust","keywords":"Proteostasis; Cell biology; Biology; Innate immune system; Transcription factor; Unfolded protein response; Signal transduction; Chaperone (clinical); Transmembrane protein; Heat shock protein; Biochemistry; Immunology; Immune system; Endoplasmic reticulum; Receptor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003334806,0.0004967402,0.0004908005,0.0002250854,0.00027755,0.0005756319,0.0002717063,0.000703893,0.003491218],"category_scores_gemma":[0.0003948627,0.0001287907,0.000453589,0.0001399952,0.0003552405,0.0005364313,0.0004678995,0.001493745,0.0008357235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007116873,"about_ca_system_score_gemma":0.0002921918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003423612,"about_ca_topic_score_gemma":0.0005232303,"domain_scores_codex":[0.9997682,0.00004596475,0.00001290493,0.00005561894,0.00005152326,0.0000658794],"domain_scores_gemma":[0.9997839,0.00003318804,0.00004815174,0.00003155424,0.00004399558,0.00005918785],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002291769,0.00006015518,0.0003343495,0.00004924246,0.000007845899,0.0001108191,0.00001504819,0.00005471695,0.9963981,0.000373239,0.0004575501,0.001909714],"study_design_scores_gemma":[0.00008989408,0.0005281736,0.01328184,0.00002744665,0.00002128424,0.0006526211,0.0001028498,0.001713334,0.9766272,0.001128686,0.005801937,0.00002461123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9383344,0.007907266,0.0372142,0.003129161,0.001085526,0.0002115932,0.002432613,0.001405641,0.008279796],"genre_scores_gemma":[0.9879827,0.001392856,0.005399004,0.0006607224,0.00008653259,0.00006928075,0.001306862,0.00008569492,0.003016289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003491218,"threshold_uncertainty_score":0.01167929,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007555148482673696,"score_gpt":0.2053453449855802,"score_spread":0.1977901965029065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}