{"id":"W2810594107","doi":"10.1128/aac.00012-18","title":"UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria","year":2018,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Malaria Research and Control","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of Allergy and Infectious Diseases; Faculty of Tropical Medicine, Mahidol University; National Institutes of Health; Medicines for Malaria Venture; Imperial College London; Mahidol University; Medical Research Council; South African Medical Research Council; University of Cape Town; National Research Foundation; Wellcome Trust","keywords":"Plasmodium falciparum; Plasmodium berghei; Malaria; Pharmacology; Plasmodium vivax; Pharmacokinetics; Biology; In vivo; Artemisinin; Immunology; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002194642,0.0003894386,0.0003133839,0.0003703877,0.0002517161,0.0003443489,0.0003467909,0.0003094403,0.002847795],"category_scores_gemma":[0.0002147878,0.0001933149,0.0002432345,0.0003094044,0.0002112697,0.0002547743,0.0002567493,0.001183058,0.0005837173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005018928,"about_ca_system_score_gemma":0.0006651832,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001423165,"about_ca_topic_score_gemma":0.002705794,"domain_scores_codex":[0.9998958,0.00001802365,0.000006119795,0.0000147394,0.00003550681,0.00002976346],"domain_scores_gemma":[0.9999405,0.000005384217,0.00001153101,0.000005030315,0.00001670564,0.00002085513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001927293,0.0006971738,0.0006593621,0.0004437357,0.00006509924,0.000527928,0.00007248415,0.003587049,0.8729547,0.002485805,0.006465435,0.110114],"study_design_scores_gemma":[0.00163968,0.0129111,0.005323849,0.00009279398,0.000135581,0.002514181,0.0000351947,0.006397361,0.889991,0.0005554642,0.08035377,0.00004996597],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.892205,0.03329919,0.02347461,0.003280398,0.0006180602,0.001608169,0.004847552,0.001546732,0.03912022],"genre_scores_gemma":[0.9502902,0.01625687,0.01694595,0.0006777509,0.00006623643,0.000313026,0.0033664,0.00006880232,0.01201464],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002847795,"threshold_uncertainty_score":0.009526789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06148259596067793,"score_gpt":0.3349540408508005,"score_spread":0.2734714448901227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}