{"id":"W2810594107","doi":"10.1128/aac.00012-18","title":"UCT943, a Next-Generation Plasmodium falciparum PI4K Inhibitor Preclinical Candidate for the Treatment of Malaria","year":2018,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Malaria Research and Control","field":"Medicine","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of Allergy and Infectious Diseases; Faculty of Tropical Medicine, Mahidol University; National Institutes of Health; Medicines for Malaria Venture; Imperial College London; Mahidol University; Medical Research Council; South African Medical Research Council; University of Cape Town; National Research Foundation; Wellcome Trust","keywords":"Plasmodium falciparum; Plasmodium berghei; Malaria; Pharmacology; Plasmodium vivax; Pharmacokinetics; Biology; In vivo; Artemisinin; Immunology; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001375241,0.0001451253,0.0002831822,0.0000371993,0.0001622722,0.00004851153,0.00007191706,0.00009476194,0.0002393027],"category_scores_gemma":[0.00001883029,0.00008608527,0.0001317635,0.00006282695,0.0001744838,0.00005028467,0.00001136799,0.00005060359,0.000006645541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002563842,"about_ca_system_score_gemma":0.00008704314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001430085,"about_ca_topic_score_gemma":0.00008354485,"domain_scores_codex":[0.9990898,0.00002766526,0.0002555217,0.0002441732,0.0001205983,0.0002621844],"domain_scores_gemma":[0.9994144,0.00006383401,0.00007872699,0.0002247208,0.0001200179,0.0000982481],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01575438,0.003121757,0.01344288,0.0001612401,0.001830844,0.00001136224,0.002250268,0.000002277443,0.6442617,0.001021242,0.1569694,0.1611727],"study_design_scores_gemma":[0.02928393,0.009537687,0.04425069,0.000086819,0.0003845465,0.00003205672,0.00007764641,0.01235204,0.4018548,0.00007463332,0.5017439,0.0003212633],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675673,0.000103044,0.0007097477,0.02973661,0.0002857248,0.001402023,0.00006348016,0.00001600831,0.0001160796],"genre_scores_gemma":[0.9914669,0.00185203,0.0005051292,0.003258483,0.001331993,0.00005686288,0.00005102219,0.00002157164,0.001456021],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3447745,"threshold_uncertainty_score":0.3510455,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06148259596067793,"score_gpt":0.3349540408508005,"score_spread":0.2734714448901227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}