{"id":"W2810630089","doi":"10.1158/1538-7445.am2018-4736","title":"Abstract 4736: Bone marrow microenvironment-induced miR-300 expression impairs natural killer cell proliferation and antitumor activity","year":2018,"lang":"en","type":"article","venue":"Cancer Research","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"","keywords":"Stromal cell; Bone marrow; Cancer research; Cytotoxic T cell; Tumor microenvironment; Immunology; Biology; Cell growth; Natural killer cell; Cell; Lymphokine-activated killer cell; Cancer cell; Interleukin 21; Immune system; Cancer; Chemistry; T cell; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008539201,0.0002123777,0.0002985701,0.0001315367,0.0001177475,0.0002005118,0.0001219447,0.0002138331,0.002787094],"category_scores_gemma":[0.00007664316,0.0001159545,0.0002133501,0.0001183079,0.0001803526,0.0001145466,0.0001514151,0.0005012519,0.0006779165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001647682,"about_ca_system_score_gemma":0.0001587956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002999962,"about_ca_topic_score_gemma":0.0003114093,"domain_scores_codex":[0.9998248,0.0000227779,0.00002095884,0.00003303404,0.00005758454,0.00004082172],"domain_scores_gemma":[0.9999355,0.00001228321,0.00001796249,0.000007017803,0.000005195386,0.00002195176],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001698832,0.0000192516,0.00006818277,0.00002601018,0.000002415441,0.00002999157,0.00000816496,0.00002265357,0.9990529,0.00003949177,0.00004607251,0.0005150578],"study_design_scores_gemma":[0.00001517925,0.0002324554,0.002488966,0.000003520958,0.000008557809,0.0001265242,0.00001887969,0.0004311211,0.9951525,0.00003503212,0.001484769,0.000002496495],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937458,0.00116531,0.002108925,0.0001102463,0.00006173037,0.00003558423,0.001022711,0.000113042,0.001636722],"genre_scores_gemma":[0.9946309,0.0004502366,0.001290811,0.00006250389,0.000009883197,0.00006341527,0.0009450623,0.00002205009,0.002525151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002787094,"threshold_uncertainty_score":0.009323716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02359080379281116,"score_gpt":0.3270572600724172,"score_spread":0.3034664562796061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}