{"id":"W2810678423","doi":"10.1016/j.celrep.2018.05.066","title":"Embryonic Microglia Derive from Primitive Macrophages and Are Replaced by cmyb-Dependent Definitive Microglia in Zebrafish","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":122,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Walloon excellence in life sciences and biotechnology; Innoviris; University of Northern Iowa; Universitair Medisch Centrum Utrecht; Fonds De La Recherche Scientifique - FNRS; Fonds pour la Formation à la Recherche dans l’Industrie et dans l’Agriculture; European Research Council; National Institutes of Health; Institut national de la recherche scientifique; Engineering Research Centers","keywords":"Microglia; Zebrafish; Biology; Embryonic stem cell; Reprogramming; Cell biology; Population; Neuroscience; Haematopoiesis; Progenitor cell; Induced pluripotent stem cell; Stem cell; Immunology; Inflammation; Cell; Medicine; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001595373,0.0003458145,0.0002062344,0.0004909034,0.0003137836,0.0002631743,0.0002913687,0.0003949247,0.001352773],"category_scores_gemma":[0.0001667178,0.000361898,0.0002881264,0.0001236267,0.0004970651,0.000380455,0.0004251451,0.0009775497,0.0005075969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005893236,"about_ca_system_score_gemma":0.0004127432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004344964,"about_ca_topic_score_gemma":0.01022867,"domain_scores_codex":[0.9998459,0.00001060765,0.00001440079,0.00003861865,0.00005039257,0.00004005263],"domain_scores_gemma":[0.9998395,0.00002232556,0.00007025162,0.00001393402,0.00002041131,0.00003354674],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006793217,0.000004405555,0.0003617809,0.00003706085,0.000002892856,0.0001797564,0.0000869897,0.0000627653,0.9972517,0.0004167406,0.00005582994,0.001472182],"study_design_scores_gemma":[0.0000354855,0.000212725,0.0200173,0.00007827285,0.00004468836,0.001073703,0.0002338367,0.00120958,0.969018,0.0004634456,0.007588516,0.00002432488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9831631,0.001922945,0.007859658,0.0002757493,0.00003960236,0.00004606067,0.001118522,0.0001767996,0.005397641],"genre_scores_gemma":[0.9752102,0.001687326,0.009446085,0.0001754528,0.00001116576,0.00008670736,0.0006776294,0.0001414828,0.01256398],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004344964,"threshold_uncertainty_score":0.008639336,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01566971995916934,"score_gpt":0.2313960107734229,"score_spread":0.2157262908142535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}