{"id":"W2810746661","doi":"10.1093/ijnp/pyw043.116","title":"PS116. Desvenlafaxine prevents white matter injury and improves the decreased phosphorylation of rate-limiting enzyme of cholesterol synthesis in a chronic mouse model of depression.","year":2016,"lang":"en","type":"article","venue":"The International Journal of Neuropsychopharmacology","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; University of Manitoba; University of Alberta; University of Saskatchewan","funders":"","keywords":"Depression (economics); Limiting; Phosphorylation; White matter; Medicine; Internal medicine; Pharmacology; Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001280494,0.0006963352,0.0005073869,0.0006035561,0.0002474949,0.0003175772,0.000496345,0.0008763495,0.002667464],"category_scores_gemma":[0.00009306478,0.0002390693,0.0003233196,0.0003249221,0.0004443664,0.0004355342,0.0001578296,0.001394719,0.0007841637],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003983642,"about_ca_system_score_gemma":0.0005404075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002180282,"about_ca_topic_score_gemma":0.003569588,"domain_scores_codex":[0.9998769,0.00001222865,0.00001486014,0.00002251481,0.00002874522,0.00004477481],"domain_scores_gemma":[0.9998714,0.000005647993,0.00004615866,0.00001113971,0.00001048619,0.00005522034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003198121,0.0003638605,0.0002374181,0.000111118,0.00004392348,0.0001231904,0.00001722195,0.0001145705,0.989211,0.0002117338,0.0003854122,0.005982526],"study_design_scores_gemma":[0.0008527697,0.003547109,0.006849714,0.00002311138,0.00009871163,0.0004111647,0.00006153549,0.0006899843,0.9831762,0.0002351545,0.004038016,0.00001648036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892808,0.0026332,0.001754586,0.0006642479,0.0002286008,0.00007245252,0.002563017,0.0004238228,0.002379428],"genre_scores_gemma":[0.9826806,0.002298452,0.001739928,0.000130977,0.0000330272,0.0001180778,0.002153872,0.00004014363,0.0108049],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002667464,"threshold_uncertainty_score":0.008923531,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01945998328074935,"score_gpt":0.290195324770439,"score_spread":0.2707353414896897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}