{"id":"W2810813040","doi":"10.1111/bdi.12659","title":"Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study","year":2018,"lang":"en","type":"article","venue":"Bipolar Disorders","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; Douglas College; McGill University Health Centre; Dalhousie University","funders":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Vetenskapsrådet; Stockholms Läns Landsting; Alfried Krupp von Bohlen und Halbach-Stiftung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Deutsche Forschungsgemeinschaft; Karolinska Institutet; Bundesministerium für Bildung und Forschung; Brain and Behavior Research Foundation","keywords":"Bipolar disorder; Age of onset; Schizophrenia (object-oriented programming); Polygenic risk score; Disease; Medicine; Schizophrenia spectrum; Psychiatry; Clinical psychology; Internal medicine; Psychosis; Genetics; Biology; Gene; Mood; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004207733,0.0002243196,0.0002194078,0.0002062031,0.0001419946,0.00002860895,0.0004263448,0.0001620797,0.00008338328],"category_scores_gemma":[0.000865708,0.0002403041,0.00007552184,0.0002751225,0.0001554121,0.00001580286,0.0002921459,0.0001504882,0.0000358314],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009000584,"about_ca_system_score_gemma":0.00008237256,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.006697295,"about_ca_topic_score_gemma":0.0583867,"domain_scores_codex":[0.9979644,0.0003561135,0.0004356013,0.0006388227,0.0001746206,0.0004304863],"domain_scores_gemma":[0.9991885,0.00005461662,0.0001211502,0.0004232795,0.00003887898,0.0001735927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00005207804,0.0003346406,0.9892355,0.000002584789,0.00004645297,0.000002866687,0.0009515977,0.0002394224,0.002940771,0.00000421413,0.00008741685,0.006102415],"study_design_scores_gemma":[0.0014759,0.0002128069,0.9719704,0.000009621686,0.00002140527,4.84462e-7,0.0008118296,0.001981165,0.00005487186,0.0001640387,0.02302891,0.000268513],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940655,0.004591191,0.00007638593,0.0004561871,0.0002280821,0.000428957,0.0001129332,0.00001602631,0.00002479645],"genre_scores_gemma":[0.9967846,0.001337707,0.0004803529,0.0002609203,0.0001755774,0.00005511781,0.0007561152,0.00003295248,0.0001166919],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0516894,"threshold_uncertainty_score":0.9999172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01138065229377451,"score_gpt":0.2798690905673143,"score_spread":0.2684884382735398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}