{"id":"W2810813040","doi":"10.1111/bdi.12659","title":"Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study","year":2018,"lang":"en","type":"article","venue":"Bipolar Disorders","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; Douglas College; McGill University Health Centre; Dalhousie University","funders":"Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii; Vetenskapsrådet; Stockholms Läns Landsting; Alfried Krupp von Bohlen und Halbach-Stiftung; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Deutsche Forschungsgemeinschaft; Karolinska Institutet; Bundesministerium für Bildung und Forschung; Brain and Behavior Research Foundation","keywords":"Bipolar disorder; Age of onset; Schizophrenia (object-oriented programming); Polygenic risk score; Disease; Medicine; Schizophrenia spectrum; Psychiatry; Clinical psychology; Internal medicine; Psychosis; Genetics; Biology; Gene; Mood; Genotype; Single-nucleotide polymorphism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002425711,0.0004636441,0.0005091922,0.001403415,0.0005797241,0.0007219253,0.0004928222,0.0004817604,0.001157903],"category_scores_gemma":[0.003796028,0.0003169946,0.000649385,0.002050124,0.0005124154,0.0003602323,0.001082237,0.0003467227,0.0001543775],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003116743,"about_ca_system_score_gemma":0.0002744434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00876386,"about_ca_topic_score_gemma":0.008699077,"domain_scores_codex":[0.9984817,0.0007902945,0.0001152564,0.0003335685,0.0001410328,0.0001382233],"domain_scores_gemma":[0.9975408,0.0004468689,0.00120141,0.0003488416,0.0001514326,0.0003106655],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001792555,0.00002039085,0.9978359,0.000009331837,0.0001507119,0.0001063077,0.0002823794,0.00003596984,0.0002305786,0.00002374466,0.00005353299,0.001071897],"study_design_scores_gemma":[0.000006884854,0.00004424031,0.999572,0.000004250151,0.00003692752,0.0001324346,0.00008881622,0.00003780817,0.00001272335,0.000007684281,0.00005429433,0.000002023539],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992354,0.0002312473,0.0001133492,0.00001689522,0.000002140294,0.000009542169,0.0001934769,0.000001487904,0.0001964612],"genre_scores_gemma":[0.9993706,0.000130166,0.00009722231,0.0000139276,0.000006346,0.000009883168,0.0003164326,0.000002157302,0.00005322295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00876386,"threshold_uncertainty_score":0.01742566,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01138065229377451,"score_gpt":0.2798690905673143,"score_spread":0.2684884382735398,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}