{"id":"W2810847500","doi":"10.1111/jth.14222","title":"Leukocytes as a reservoir of circulating oncogenic DNA and regulatory targets of tumor‐derived extracellular vesicles","year":2018,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"Jewish General Hospital; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"HRAS; Extracellular vesicle; Microvesicles; Extracellular; Biology; Chemistry; Cell biology; Cancer research; Molecular biology; Mutation; Biochemistry; Gene; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005892585,0.0001811589,0.0004400861,0.00009788226,0.000100937,0.00002109926,0.0002095026,0.0001160532,0.00003822363],"category_scores_gemma":[0.0002704144,0.0001653766,0.0001905157,0.00009856813,0.0005560569,0.00002291002,0.0001732216,0.0001045274,6.80223e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001649689,"about_ca_system_score_gemma":0.0001388714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001762716,"about_ca_topic_score_gemma":0.000007063471,"domain_scores_codex":[0.9984641,0.0001212477,0.00069706,0.0002375082,0.0002793468,0.0002007558],"domain_scores_gemma":[0.9982667,0.00004404904,0.0008272164,0.000320978,0.0003709952,0.0001700922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002155521,0.0001206885,0.008730599,0.0001244712,0.000297082,0.00001223103,0.0003131987,0.000007764194,0.9875479,0.00006501045,0.0003685312,0.002196994],"study_design_scores_gemma":[0.0009379928,0.0008070283,0.03086013,0.0001650958,0.0001943818,0.0001025941,0.0005266833,0.00004256984,0.964956,0.0005591325,0.0006846652,0.0001636845],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808061,0.01863109,0.0001315829,0.0001332156,0.00008079543,0.0001045289,0.00001857221,0.00000298586,0.00009115755],"genre_scores_gemma":[0.995472,0.001109851,0.003112498,0.00005416359,0.0001997947,0.0000012615,0.00000477412,0.00002788765,0.00001777395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02259184,"threshold_uncertainty_score":0.6743863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02760838084107154,"score_gpt":0.2927314323836572,"score_spread":0.2651230515425856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}