{"id":"W2810878132","doi":"10.1371/journal.pone.0199632","title":"Extracellular matrix surface regulates self-assembly of three-dimensional placental trophoblast spheroids","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Tissue Engineering and Regenerative Medicine","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; McMaster University Medical Centre","funders":"Institute of Human Development, Child and Youth Health; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Canada Excellence Research Chairs, Government of Canada","keywords":"Cell biology; Matrigel; Trophoblast; Spheroid; Extracellular matrix; Cell fusion; Biology; Integrin; Laminin; Matrix metalloproteinase; In vitro; Cell; Chemistry; Placenta; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001773453,0.0001856059,0.0002061279,0.0001807857,0.0001530835,0.0004236626,0.0001052607,0.0001792504,0.000403475],"category_scores_gemma":[0.0002022883,0.0002128863,0.0002180694,0.000116528,0.0001661969,0.0001615761,0.0002232369,0.0002812993,0.0002625906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003370238,"about_ca_system_score_gemma":0.0001464433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001323079,"about_ca_topic_score_gemma":0.002361292,"domain_scores_codex":[0.99984,0.00003736983,0.00002053553,0.00002471975,0.00005024898,0.00002708972],"domain_scores_gemma":[0.9997651,0.00007709495,0.00005467831,0.00002911441,0.00003285089,0.00004107893],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002042989,0.000005172643,0.0001292803,0.00001173965,0.000002111706,0.00003606683,0.00004303982,0.0001092658,0.9993556,0.00004685841,0.00002364928,0.0002168015],"study_design_scores_gemma":[0.000007802676,0.00006949285,0.007356707,0.000006273491,0.000009486528,0.0001327214,0.00008335079,0.003464756,0.986948,0.00005668586,0.001858828,0.000005955764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993827,0.000709823,0.003743766,0.00005312859,0.00002036968,0.00003193453,0.0002531814,0.00005526681,0.001305442],"genre_scores_gemma":[0.9946359,0.0004090447,0.003472085,0.00003284148,0.00000479365,0.00002689016,0.0003937476,0.00002843994,0.0009963574],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001323079,"threshold_uncertainty_score":0.00263083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02053471156479589,"score_gpt":0.2321281689619582,"score_spread":0.2115934573971623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}