{"id":"W2810902309","doi":"10.1016/j.yexcr.2018.06.033","title":"Rosiglitazone rescues human neural stem cells from amyloid-beta induced ER stress via PPARγ dependent signaling","year":2018,"lang":"en","type":"article","venue":"Experimental Cell Research","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Taipei Hospital; Ministry of Science and Technology","keywords":"Biology; Peroxisome proliferator-activated receptor; Neuroprotection; Unfolded protein response; Nuclear receptor; Cell biology; PPAR agonist; Endoplasmic reticulum; Neural stem cell; Signal transduction; Amyloid beta; Receptor; Neuroscience; Stem cell; Transcription factor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003134564,0.0002955958,0.0002293374,0.00009896586,0.0004970125,0.0001717971,0.000596384,0.0002143734,0.0004642565],"category_scores_gemma":[0.00000732953,0.0002768407,0.000143724,0.0001319331,0.0003471393,0.00001582122,0.0006784768,0.0003258407,0.0001454123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007963679,"about_ca_system_score_gemma":0.00007395667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001062639,"about_ca_topic_score_gemma":0.00009570398,"domain_scores_codex":[0.996796,0.0003950658,0.0003496705,0.0008815561,0.0008001426,0.0007776226],"domain_scores_gemma":[0.9985195,0.00004541965,0.00007577406,0.0007480368,0.0001958496,0.0004153882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002700782,0.0004461227,0.001197349,0.00001773002,0.00003229829,0.00003759707,0.0003545804,0.0000138138,0.9958935,0.00001502149,0.001405026,0.0003169121],"study_design_scores_gemma":[0.001098247,0.0008914083,0.0001782297,0.00002682516,0.000009679658,0.000001631666,0.002154015,0.0001472194,0.9946371,0.0000185062,0.0005214094,0.0003157132],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920654,0.002534183,0.00004412508,0.00002365731,0.0002538717,0.0004030292,0.0000963434,0.00002671942,0.004552681],"genre_scores_gemma":[0.9968631,0.0000323201,0.00009377864,0.0000643077,0.0008609137,0.00008814192,0.0001927278,0.00006342602,0.001741255],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00479774,"threshold_uncertainty_score":0.9999683,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05011841811985836,"score_gpt":0.3546162210382962,"score_spread":0.3044978029184379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}