{"id":"W2810927295","doi":"10.1017/cjn.2018.93","title":"B.05 Nusinersen in infants who initiate treatment in a presymptomatic stage of spinal muscular atrophy (SMA): interim results from the Phase 2 NURTURE study","year":2018,"lang":"en","type":"article","venue":"Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques","topic":"Neurogenetic and Muscular Disorders Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Systems, Applications & Products in Data Processing (Canada); Toronto Public Health","funders":"","keywords":"Spinal muscular atrophy; Medicine; SMA*; Clinical endpoint; Pediatrics; Interim analysis; Internal medicine; Randomized controlled trial; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.00324626,0.0003074082,0.0006887769,0.0009823724,0.0006354401,0.0002260732,0.001261782,0.0001269781,0.000108333],"category_scores_gemma":[0.002588933,0.0001698898,0.0002161753,0.001721848,0.00544146,0.0003631482,0.00008468394,0.0009110858,0.000001521396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002176264,"about_ca_system_score_gemma":0.003197711,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.01608863,"about_ca_topic_score_gemma":0.2538429,"domain_scores_codex":[0.9947667,0.001555996,0.001200417,0.0005548057,0.0009083538,0.001013731],"domain_scores_gemma":[0.9973441,0.0004720416,0.000610313,0.0002812451,0.0003435233,0.0009487475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002228795,0.0005978673,0.9628157,0.00001154669,0.00005207639,0.01819117,0.004665909,0.0006167773,0.0002124085,0.00003367743,0.0001306661,0.01044341],"study_design_scores_gemma":[0.005073419,0.2246047,0.7588976,0.0001857076,0.00006782633,0.003330405,0.002304957,0.003037049,0.0001833746,0.001084875,0.001005185,0.0002248942],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950438,0.000741476,0.000007213217,0.002722467,0.0003058826,0.0006279423,0.00004013546,0.000005284995,0.0005058323],"genre_scores_gemma":[0.998098,0.0002621237,0.0002340573,0.001183791,0.0001862812,0.000006250349,5.953432e-7,0.00001068045,0.00001822402],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2377543,"threshold_uncertainty_score":0.9972652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0640228855045521,"score_gpt":0.3608547446600018,"score_spread":0.2968318591554497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}