{"id":"W2810933650","doi":"10.1002/art.40498","title":"<i>IL1RN</i> Variation Influences Both Disease Susceptibility and Response to Recombinant Human Interleukin‐1 Receptor Antagonist Therapy in Systemic Juvenile Idiopathic Arthritis","year":2018,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Arthritis Network; National Human Genome Research Institute; Medical Research Council; Chugai Pharmaceutical; National Institutes of Health; Canadian Institutes of Health Research; Medac; Swedish Orphan Biovitrum; Versus Arthritis; Hospital for Sick Children; University of Manchester; Great Ormond Street Hospital for Children; Arthritis Research UK; Dalhousie University; University of Toronto; University of Glasgow; Newcastle University; Bundesministerium für Bildung und Forschung; NHS Blood and Transplant; BC Children's Hospital; National Institute for Health and Care Research; Arthritis Society; University of Alberta; Alder Hey Children's NHS Foundation Trust; Wellcome Trust; University College London; Université de Sherbrooke; Baxalta; University of Nottingham; Cincinnati Children's Hospital Medical Center; McGill University; Amgen","keywords":"Interleukin 1 receptor antagonist; Juvenile; Arthritis; Receptor antagonist; Immunology; Medicine; Recombinant DNA; Antagonist; Receptor; Internal medicine; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002226272,0.0002998882,0.00102491,0.0004024529,0.0003777765,0.00008210734,0.0002175771,0.000213954,0.0002948598],"category_scores_gemma":[0.0009082464,0.0002959772,0.00009372261,0.0004238299,0.0006315782,0.0002856675,0.0001495653,0.0003846638,0.0002278422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001921448,"about_ca_system_score_gemma":0.0005939779,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001231083,"about_ca_topic_score_gemma":0.001812587,"domain_scores_codex":[0.996075,0.0009284565,0.001250579,0.000765553,0.0003240814,0.0006563215],"domain_scores_gemma":[0.9983609,0.0001619721,0.0002261393,0.0006726511,0.0002317546,0.0003465468],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01040579,0.0006576214,0.7215,0.0003253023,0.0000701532,0.0003514712,0.009704727,0.000001104922,0.1640476,0.001308937,0.001669681,0.08995756],"study_design_scores_gemma":[0.01490851,0.007836935,0.9497394,0.006729322,0.00001439986,0.001199907,0.002157418,0.00009723125,0.003291063,0.00181535,0.01138027,0.0008302157],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862092,0.0095718,0.00003336653,0.002429514,0.0003811538,0.001148104,0.00001761315,0.0001146172,0.00009459743],"genre_scores_gemma":[0.9916255,0.007408907,0.00007714138,0.0004401362,0.00003363925,0.00022878,0.00002903141,0.00004182828,0.0001149895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2282393,"threshold_uncertainty_score":0.9999492,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369322703799165,"score_gpt":0.287296160403392,"score_spread":0.2736029333654004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}