{"id":"W2810933650","doi":"10.1002/art.40498","title":"<i>IL1RN</i> Variation Influences Both Disease Susceptibility and Response to Recombinant Human Interleukin‐1 Receptor Antagonist Therapy in Systemic Juvenile Idiopathic Arthritis","year":2018,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Autoimmune and Inflammatory Disorders Research","field":"Medicine","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; University of Toronto","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Arthritis Network; National Human Genome Research Institute; Medical Research Council; Chugai Pharmaceutical; National Institutes of Health; Canadian Institutes of Health Research; Medac; Swedish Orphan Biovitrum; Versus Arthritis; Hospital for Sick Children; University of Manchester; Great Ormond Street Hospital for Children; Arthritis Research UK; Dalhousie University; University of Toronto; University of Glasgow; Newcastle University; Bundesministerium für Bildung und Forschung; NHS Blood and Transplant; BC Children's Hospital; National Institute for Health and Care Research; Arthritis Society; University of Alberta; Alder Hey Children's NHS Foundation Trust; Wellcome Trust; University College London; Université de Sherbrooke; Baxalta; University of Nottingham; Cincinnati Children's Hospital Medical Center; McGill University; Amgen","keywords":"Interleukin 1 receptor antagonist; Juvenile; Arthritis; Receptor antagonist; Immunology; Medicine; Recombinant DNA; Antagonist; Receptor; Internal medicine; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006171512,0.0003183314,0.0003002194,0.0003255534,0.0001660535,0.0003760122,0.0001687113,0.000313615,0.001566558],"category_scores_gemma":[0.001722899,0.000138855,0.0003213042,0.0003262594,0.0003092961,0.0001233489,0.0001500855,0.0003105983,0.0001821548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001370331,"about_ca_system_score_gemma":0.0001150579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009470775,"about_ca_topic_score_gemma":0.0007456235,"domain_scores_codex":[0.99939,0.0002460505,0.00005276192,0.000198594,0.00006431074,0.00004825632],"domain_scores_gemma":[0.9987271,0.0006647352,0.0004096219,0.00007711979,0.00004415118,0.00007718343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001950937,0.00008473359,0.9632704,0.00003253057,0.0003509823,0.0004803081,0.000184277,0.000394398,0.0280782,0.00005989066,0.0001647233,0.004948728],"study_design_scores_gemma":[0.00003963952,0.0002385695,0.9962307,0.000007348233,0.0001349214,0.0008868951,0.00004558119,0.0008645847,0.001358867,0.00004186623,0.0001461167,0.000004908934],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996179,0.00009570557,0.0001146882,0.0000179311,0.000002919263,0.000002096647,0.00005012219,0.000003722264,0.00009495662],"genre_scores_gemma":[0.9997683,0.00002038589,0.00009498159,0.00001522527,0.00000591505,0.000002188902,0.00004682397,0.000003526524,0.00004249253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001566558,"threshold_uncertainty_score":0.005240679,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01369322703799165,"score_gpt":0.287296160403392,"score_spread":0.2736029333654004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}