{"id":"W2810936120","doi":"10.1038/s41598-018-28608-2","title":"Repurposing drugs to target the malaria parasite unfolding protein response","year":2018,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Western Economic Diversification Canada; Congressionally Directed Medical Research Programs; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health; University of Saskatchewan; Canadian Light Source; Tulane University; National Research Council Canada; Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS)","keywords":"Plasmodium falciparum; Drug repositioning; Parasite hosting; Chaperone (clinical); Drug; Biology; Malaria; Unfolded protein response; Drug discovery; Drug resistance; Repurposing; Infectious disease (medical specialty); Endoplasmic reticulum; Virology; Disease; Microbiology; Cell biology; Pharmacology; Biochemistry; Medicine; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001470368,0.0003474902,0.0004466312,0.0002812656,0.0001441431,0.0002977202,0.0002314552,0.000282108,0.001874001],"category_scores_gemma":[0.0001256421,0.0001291217,0.0002106863,0.0001808175,0.0001865492,0.0002385945,0.0002064508,0.0006002491,0.0006854721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001898915,"about_ca_system_score_gemma":0.0001753076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001552732,"about_ca_topic_score_gemma":0.0004175858,"domain_scores_codex":[0.9999344,0.00001422041,0.000004504502,0.00001135053,0.00002085158,0.00001460024],"domain_scores_gemma":[0.9999437,0.00001098582,0.00001813312,0.000006379064,0.00001135867,0.000009423223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001524856,0.0001470185,0.0003653379,0.000326515,0.00001916381,0.0002113244,0.00002948052,0.0005433674,0.9716665,0.001192922,0.0005396594,0.02480623],"study_design_scores_gemma":[0.0001038748,0.001763561,0.002566049,0.00002941789,0.00005968385,0.001035175,0.00003509067,0.001564972,0.9501629,0.0005474085,0.04211652,0.00001546034],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8992628,0.06143969,0.02062347,0.001786561,0.0003394678,0.0004601253,0.001147197,0.00039525,0.0145453],"genre_scores_gemma":[0.9356894,0.04020889,0.01535445,0.0006715973,0.0001348508,0.0001317805,0.0009141217,0.00004497817,0.006849907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001874001,"threshold_uncertainty_score":0.006269157,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006395248908220648,"score_gpt":0.25541211571353,"score_spread":0.2490168668053094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}