{"id":"W2810953135","doi":"10.1021/acs.jmedchem.8b00154","title":"Novel Highly Potent and Metabolically Resistant Oxoeicosanoid (OXE) Receptor Antagonists That Block the Actions of the Granulocyte Chemoattractant 5-Oxo-6,8,11,14-Eicosatetraenoic Acid (5-oxo-ETE)","year":2018,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University Health Centre","funders":"National Heart, Lung, and Blood Institute; Natural Sciences and Engineering Research Council of Canada; Institute of Circulatory and Respiratory Health; Canadian Institutes of Health Research; American Asthma Foundation","keywords":"Chemistry; Antagonist; Eosinophil; Chemotaxis; Potency; Pharmacology; Metabolite; Receptor; IC50; Biochemistry; Stereochemistry; In vitro; Asthma; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001658196,0.0003940852,0.0004592107,0.0001722554,0.0001110318,0.0002860975,0.0003312471,0.0002782725,0.0009495418],"category_scores_gemma":[0.0001169744,0.0001366917,0.0002039902,0.0001625387,0.0002137895,0.0002159161,0.0002188357,0.0005634446,0.0004305787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000177324,"about_ca_system_score_gemma":0.0002459726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003574917,"about_ca_topic_score_gemma":0.001133435,"domain_scores_codex":[0.9998778,0.00002024028,0.000009877835,0.00002144373,0.00002720103,0.00004336158],"domain_scores_gemma":[0.9999584,0.000004616573,0.00001325904,0.000002554717,0.000005624059,0.00001555001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000360869,0.000204905,0.0002052846,0.0001110355,0.00002650069,0.0001889663,0.00005175368,0.0004085199,0.9797904,0.0005552568,0.0004115099,0.01768488],"study_design_scores_gemma":[0.001221547,0.01376077,0.008395831,0.00003472996,0.0001941313,0.002711611,0.00009289204,0.00311143,0.9325723,0.0003731395,0.03746072,0.00007099162],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9682745,0.01367959,0.01124016,0.0002877511,0.0001117175,0.0002784125,0.0005872592,0.000195171,0.005345588],"genre_scores_gemma":[0.9764302,0.007353448,0.009348416,0.0003758399,0.000062661,0.0001465015,0.001034758,0.00001967169,0.005228485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009495418,"threshold_uncertainty_score":0.00317651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0185588096207203,"score_gpt":0.2639385019462303,"score_spread":0.24537969232551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}