{"id":"W2810959734","doi":"10.1093/hmg/ddy245","title":"Pharmacological and physiological activation of AMPK improves the spliceopathy in DM1 mouse muscles","year":2018,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research; Muscular Dystrophy Canada","keywords":"AMPK; Biology; Myotonic dystrophy; Protein kinase A; Skeletal muscle; Duchenne muscular dystrophy; Endocrinology; Phenotype; Myopathy; Internal medicine; Signal transduction; AMP-activated protein kinase; Myocyte; Kinase; Cell biology; Genetics; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001674741,0.0005724486,0.0004428856,0.0003646547,0.0001909799,0.0002304579,0.0002737485,0.0004285942,0.001704543],"category_scores_gemma":[0.00007973024,0.0001425329,0.0002431121,0.0001773434,0.0002322608,0.0002086496,0.000176862,0.0008067218,0.0003940192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001863075,"about_ca_system_score_gemma":0.00018282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003833048,"about_ca_topic_score_gemma":0.0008787513,"domain_scores_codex":[0.9998813,0.00001858608,0.0000190588,0.00003260603,0.00002565892,0.00002285414],"domain_scores_gemma":[0.9999195,0.000008205474,0.00002811703,0.000009734155,0.000008266362,0.00002617796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007092021,0.0001875832,0.0001638829,0.00014756,0.00001771888,0.00004916164,0.00001816336,0.00007412894,0.9950609,0.00008513827,0.0001078276,0.003378718],"study_design_scores_gemma":[0.0002968401,0.00530276,0.01031823,0.00005502638,0.0001230917,0.0004748878,0.00008572164,0.0006929657,0.9745939,0.0001298174,0.007908175,0.00001866552],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908258,0.004736461,0.00154173,0.0002496517,0.00009762451,0.00004853775,0.0008262363,0.0001997615,0.001474136],"genre_scores_gemma":[0.9877012,0.00435762,0.002730637,0.000189271,0.00003434491,0.00009531468,0.001218792,0.00005121321,0.003621547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001704543,"threshold_uncertainty_score":0.005702257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05875951939936457,"score_gpt":0.317130582260829,"score_spread":0.2583710628614644,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}