{"id":"W2810974346","doi":"10.1126/scisignal.aam5855","title":"Thyroid hormone receptor and ERRα coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function","year":2018,"lang":"en","type":"article","venue":"Science Signaling","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":153,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Medical Research Council; Canadian Institutes of Health Research","keywords":"Mitophagy; Mitochondrial biogenesis; Mitochondrial fission; PPARGC1A; Cell biology; Mitochondrion; Thyroid hormone receptor; Autophagy; Biology; Oxidative phosphorylation; Citric acid cycle; Coactivator; Biochemistry; Receptor; Transcription factor; Metabolism","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001604555,0.0002568391,0.0003286604,0.0002213402,0.0001403129,0.0002430411,0.0001942409,0.0001931023,0.00183763],"category_scores_gemma":[0.0001288956,0.0001529672,0.0003618894,0.000167269,0.0002854281,0.0001879735,0.0001569382,0.0005243449,0.0003890755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003187669,"about_ca_system_score_gemma":0.0002662892,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000701429,"about_ca_topic_score_gemma":0.002109064,"domain_scores_codex":[0.9998516,0.00002669251,0.00002199954,0.00002911976,0.00003200401,0.00003852646],"domain_scores_gemma":[0.9999131,0.00001150857,0.00002261063,0.00001654379,0.00001330318,0.00002283772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009373423,0.00004191356,0.0006368012,0.00007584639,0.00003011967,0.0001031318,0.00002362944,0.0001137102,0.9938618,0.0001728797,0.000151351,0.003851383],"study_design_scores_gemma":[0.0001053782,0.000722927,0.01642147,0.00001180107,0.0001066276,0.0008385656,0.0001072567,0.001006943,0.9738551,0.0001748675,0.006637305,0.00001176281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882329,0.005024612,0.003865327,0.0002846215,0.00008744934,0.0000190976,0.0005054837,0.0001731565,0.001807371],"genre_scores_gemma":[0.9914086,0.001630808,0.001658729,0.00007514912,0.0000218114,0.00002570595,0.0005008167,0.00002821217,0.004649958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00183763,"threshold_uncertainty_score":0.006147504,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0110445847152814,"score_gpt":0.2447945849727046,"score_spread":0.2337500002574232,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}